A review of cumulative toxic effects of environmental endocrine disruptors on the zebrafish immune system: Characterization methods, toxic effects and mechanisms

被引：4
|
作者：
Li, Zixu [1 ]
Li, Muge [1 ]
Li, Dan [1 ]
Chen, Yao [1 ,2 ]
Feng, Weiwei [1 ,2 ]
Zhao, Ting [3 ]
Yang, Liuqing [3 ]
Mao, Guanghua [1 ]
Wu, Xiangyang [1 ]
机构：
[1] Jiangsu Univ, Sch Environm & Safety Engn, Sch Emergency Management, 301 Xuefu Rd, Zhenjiang 212013, Peoples R China
[2] Jiangsu Univ, Inst Environm Hlth & Ecol Safety, 301 Xuefu Rd, Zhenjiang 212013, Jiangsu, Peoples R China
[3] Jiangsu Univ, Sch Chem & Chem Engn, 301 Xuefu Rd, Zhenjiang 212013, Peoples R China
来源：
ENVIRONMENTAL RESEARCH | 2024年 / 246卷
关键词：
Environmental endocrine disruptors; Immune system; Characterization approach; Immunotoxicity effects; Mechanism; EARLY-LIFE STAGE; NF-KAPPA-B; OXIDATIVE STRESS; DANIO-RERIO; GENE-EXPRESSION; BISPHENOL-A; DEVELOPMENTAL TOXICITY; FLAME RETARDANTS; INNATE IMMUNITY; RELEVANT CONCENTRATIONS;
D O I：
10.1016/j.envres.2023.118010
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Environmental endocrine disrupting chemicals (EDCs), are a type of exogenous organic pollutants, are ubiquitous in natural aquatic environments. Currently, in addition to neurological, endocrine, developmental and reproductive toxicity, ecotoxicology studies on immunotoxicity are receiving increasing attention. In this review, the composition of immune system of zebrafish, the common indicators of immunotoxicity, the immunotoxicity of EDCs and their molecular mechanism were summarized. We reviewed the immunotoxicity of EDCs on zebrafish mainly in terms of immune organs, immunocytes, immune molecules and immune functions, meanwhile, the possible molecular mechanisms driving these effects were elucidated in terms of endocrine disruption, dysregulation of signaling pathways, and oxidative damage. Hopefully, this review will provide a reference for further investigation of the immunotoxicity of EDCs.
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页数：18
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