A comment to improve tumor-treating fields therapy

被引:0
|
作者
Fioranelli, Massimo [1 ]
Sepehri, Alireza [1 ]
机构
[1] Ist Terapie Sistem Integrate, Via Flaminia 499, I-00191 Rome, Italy
来源
AIMS BIOENGINEERING | 2023年 / 10卷 / 01期
关键词
tumor; TTFields; therapy; bubble; blood;
D O I
10.3934/bioeng.2023002
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Recent investigations have shown that special frequencies and intensities of electromagnetic waves could control the differentiations of some types of cells. Using this fact, tumor-treating fields (TTFields) therapy has been proposed as a technique which uses alternating electric fields of intermediate frequency (similar to 100-500 kHz) and low intensity (1-3 V/cm) to disrupt the cell divisions of tumors. However, this technique may have harmful effects on ionic liquids around normal cells. For example, electrodes could induce an extra electrical current within blood vessels. To observe these effects, we connected electrodes to a slide that includes water and some extra ions and put them under a 1000x microscope. We found that some ions, microbes and cells move toward negative electrons and some go away. These attractions of cells by electrodes could cause the destruction of the brain. We also found some electrical currents within the liquid emerge which absorb or repel water molecules and induce some bubbles. If these types of bubbles arise within the blood vessels, they can exert a force on the membranes of normal cells and destroy them. To avoid these problems, we suggest that electrodes should be replaced by some electromagnetic sender/receiver which emits some special frequencies. These frequencies could be absorbed only by blood vessels around the tumors because these vessels may be created only to provide the needed food for tumor cells and thus have a different potential and electrical current as compared to vessels around normal cells. Thus, these tumor vessels could act as the antenna for TTFields.
引用
收藏
页码:13 / 23
页数:11
相关论文
共 50 条
  • [31] Quality of Life in Patients With Glioblastoma Treated With Tumor-Treating Fields
    Kwan, Kevin
    Schneider, Julia R.
    Boockvar, John A.
    JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2018, 319 (17): : 1822 - 1823
  • [32] A Shock to the System: Tumor-Treating Fields Plus Temozolomide for Glioblastoma
    Alexiades, Nikita
    McKhann, Guy M., II
    NEUROSURGERY, 2018, 82 (05) : E115 - E116
  • [33] Enhancing glioblastoma treatment through the integration of tumor-treating fields
    Szklener, Katarzyna
    Bilski, Mateusz
    Nieoczym, Karolina
    Mandziuk, Dominika
    Mandziuk, Slawomir
    FRONTIERS IN ONCOLOGY, 2023, 13
  • [34] Delayed Pseudoprogression in Glioblastoma Patients Treated With Tumor-Treating Fields
    Saito, Norihiko
    Hirai, Nozomi
    Sato, Sho
    Hayashi, Morito
    Iwabuchi, Satoshi
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2024, 16 (02)
  • [35] Response Patterns of Recurrent Glioblastomas Treated With Tumor-Treating Fields
    Vymazal, Josef
    Wong, Eric T.
    SEMINARS IN ONCOLOGY, 2014, 41 : S14 - S24
  • [36] Development of a Method for Improving the Electric Field Distribution in Patients Undergoing Tumor-Treating Fields Therapy
    Sung, Jiwon
    Seo, Jaehyeon
    Jo, Yunhui
    Yoon, Myonggeun
    Hwang, Sang-Gu
    Kim, Eun Ho
    JOURNAL OF THE KOREAN PHYSICAL SOCIETY, 2018, 73 (10) : 1577 - 1583
  • [37] PTEN MUTATIONS PREDICT BENEFIT FROM TUMOR-TREATING FIELDS THERAPY IN PATIENTS WITH RECURRENT GLIOBLASTOMA
    Dono, Antonio
    Mitra, Sonali
    Takayasu, Takeshi
    Zhu, Jay-Jiguang
    Tandon, Nitin
    Esquenazi, Yoshua
    Ballester, Leomar Y.
    NEURO-ONCOLOGY, 2020, 22 : 11 - 12
  • [38] Development of a Method for Improving the Electric Field Distribution in Patients Undergoing Tumor-Treating Fields Therapy
    Jiwon Sung
    Jaehyeon Seo
    Yunhui Jo
    Myonggeun Yoon
    Sang-Gu Hwang
    Eun Ho Kim
    Journal of the Korean Physical Society, 2018, 73 : 1577 - 1583
  • [39] Feasibility of Treating High Grade Gliomas in Children with Tumor-Treating Fields: A Case Series
    Crawford, John
    Saria, Marlon G.
    Dhall, Girish
    Margol, Ashley
    Kesari, Santosh
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2020, 12 (10)
  • [40] Quality of Life in Patients With Glioblastoma Treated With Tumor-Treating Fields Reply
    Stupp, Roger
    Ram, Zvi
    JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2018, 319 (17): : 1823 - 1823