How clonal hematopoiesis promotes inflammation at a single-cell level

被引：1
|
作者：
Chavkin, Nicholas W. [1 ]
Evans, Megan A. [1 ]
Walsh, Kenneth [1 ]
机构：
[1] Univ Virginia, Sch Med, Robert M Berne Cardiovasc Res Ctr, Charlottesville, VA 22908 USA
来源：
NATURE CARDIOVASCULAR RESEARCH | 2023年 / 2卷 / 09期
关键词：
HEART-FAILURE; DNMT3A; TET2;
D O I：
10.1038/s44161-023-00323-w
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A method to identify and analyze clonal hematopoiesis in clinical blood samples at single-cell resolution reveals cell-intrinsic and paracrine effects of DNMT3A mutations in circulating monocytes, T cells and natural killer cells in the setting of heart failure.
引用
收藏
页码：801 / 802
页数：2
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