A long lifetime and highly sensitive wearable microneedle sensor for the continuous real-time monitoring of glucose in interstitial fluid

被引:19
|
作者
Yin, Sijie [1 ]
Yu, Zhiqiang [2 ]
Song, Ningning [3 ]
Guo, Zhanjun [3 ]
Li, Wei [3 ]
Ma, Jinhang [1 ]
Wang, Xiaoyan [3 ]
Liu, Junyao [4 ]
Liang, Minmin [3 ]
机构
[1] Beijing Inst Technol, Sch Automat, 5 South St, Beijing 100081, Peoples R China
[2] Beijing Inst Technol, Yangtze Delta Reg Acad, Jiaxing 314000, Peoples R China
[3] Beijing Inst Technol, Expt Ctr Adv Mat, Sch Mat Sci & Engn, 5 South St, Beijing 100081, Peoples R China
[4] Beijing Univ Technol, Fan Gongxiu Honors Coll, 100 Pingleyuan, Beijing 100124, Peoples R China
来源
BIOSENSORS & BIOELECTRONICS | 2024年 / 244卷
基金
中国国家自然科学基金;
关键词
Continuous glucose monitoring; Biosensor; Microneedle; Skin patch; BIOSENSOR;
D O I
10.1016/j.bios.2023.115822
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
The short lifetime and low sensitivity of the current glucose electrochemical sensors are two major issues for implementing continuous real-time monitoring of glucose in vivo. Here we show that a unique microneedle-based glucose monitoring skin patch (termed here MGMSP) can continuously measure glucose in real time in live animals with micromolar sensitivity and over 14 days of service life. This MGMSP employs a glucose oxidase (GOD) and carbon nanotube (CNT) modified hollow syringe as electrochemical sensor for glucose monitoring, an integrated circuit for signal processing and transmission, and the real-time glucose levels are displayed on smartphone via Bluetooth. The designed microneedle device protects the stability of the sensing molecules immobilized within the inner surface of hollow syringe and simultaneously the interior space of hollow syringe substantially increases the amount of immobilized sensing molecules. This microneedle design thus extends the lifetime as well as improves the detection sensitivity. The final MGMSP enables the continuous real-time monitoring of glucose in the interstitial fluid of live rats. This innovative microneedle-based MGMSP could potentially provide the public with high-accuracy continual glucose monitoring.
引用
收藏
页数:8
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