Double-Negative T (DNT) Cells in Patients with Systemic Lupus Erythematosus

被引:6
|
作者
Poddighe, Dimitri [1 ,2 ]
Dossybayeva, Kuanysh [1 ]
Kozhakhmetov, Samat [3 ]
Rozenson, Rafail [4 ]
Assylbekova, Maykesh [2 ]
机构
[1] Nazarbayev Univ, Sch Med, Astana 010000, Kazakhstan
[2] Univ Med Ctr, Natl Res Ctr Maternal & Child Hlth, Clin Acad Dept Pediat, Astana 010000, Kazakhstan
[3] Natl Lab Astana, Ctr Life Sci, Astana 010000, Kazakhstan
[4] Astana Med Univ, Dept Childrens Dis n1, Astana 010000, Kazakhstan
关键词
double-negative T cells; DN T cells; DNT cells; systemic lupus erythematosus; lupus; MRL/lpr mouse; POTENTIAL BIOMARKER; DISEASE-ACTIVITY; HELPER-CELLS; AUTOANTIBODIES; IL-17; MICE; MANAGEMENT; INFILTRATE; INDUCTION; BASOPHILS;
D O I
10.3390/biomedicines12010166
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Double-negative T (DNT) cells are a rare and unconventional T-lymphocyte subpopulation lacking both CD4 and CD8 markers. Their immunopathological roles and clinical relevance have yet to be elucidated. Beyond autoimmune lymphoproliferative syndrome (ALPS), these cells may also play a role in rheumatic disorders, including systemic lupus erythematosus (SLE); indeed, these two diseases share several autoimmune manifestations (including nephritis). Moreover, one of the main experimental murine models used to investigate lupus, namely the MRL/lpr mouse, is characterized by an expansion of DNT cells, which can support the production of pathogenic autoantibodies and/or modulate the immune response in this context. However, lupus murine models are not completely consistent with their human SLE counterpart, of course. In this mini review, we summarize and analyze the most relevant clinical studies investigating the DNT cell population in SLE patients. Overall, based on the present literature review and analysis, DNT cell homeostasis seems to be altered in patients with SLE. Indeed, most of the available clinical studies (which include both adults and children) reported an increased DNT cell percentage in SLE patients, especially during the active phases, even though no clear correlation with disease activity and/or inflammatory parameters has been clearly established. Well-designed, standardized, and longitudinal clinical studies focused on DNT cell population are needed, in order to further elucidate the actual contribution of these cells in SLE pathogenesis and their interactions with other immune cells (also implicated and/or altered in SLE, such as basophils), and clarify whether their expansion and/or immunophenotypic aspects may have any immunopathological relevance (and, then, represent potential disease markers and, in perspective, even therapeutic targets) or are just an unspecific epiphenomenon of autoimmunity.
引用
收藏
页数:15
相关论文
共 50 条
  • [31] Preferential Infiltration Of Double-Negative (DN) T Cells Into The Glomeruli Of NZM 2328 Lupus Mice
    Yu, Ning
    Guo, Shunhua
    Stohl, William
    Jacob, Chaim O.
    ARTHRITIS AND RHEUMATISM, 2013, 65 : S237 - S238
  • [32] Antitumor activity mediated by double-negative T cells
    Young, KJ
    Kay, LS
    Phillips, MJ
    Zhang, L
    CANCER RESEARCH, 2003, 63 (22) : 8014 - 8021
  • [33] mTOR activation triggers proinflammatory expansion of IL-4-producing and necrosis-prone double-negative T cells, precedes flares, and serves as target for treatment in patients with systemic lupus erythematosus
    Zhi-Wei Lai
    Rebecca Borsuk
    Ashwini Shadakshari
    Jianghong Yu
    Maha Dawood
    Ricardo Garcia
    Lisa Francis
    Hajra Tily
    Adam Bartos
    Stephen V Faraone
    Paul Phillips
    Andras Perl
    Arthritis Research & Therapy, 16
  • [34] mTOR activation triggers proinflammatory expansion of IL-4-producing and necrosis-prone double-negative T cells, precedes flares, and serves as target for treatment in patients with systemic lupus erythematosus
    Lai, Zhi-Wei
    Borsuk, Rebecca
    Shadakshari, Ashwini
    Yu, Jianghong
    Dawood, Maha
    Garcia, Ricardo
    Francis, Lisa
    Tily, Hajra
    Bartos, Adam
    Faraone, Stephen V.
    Phillips, Paul
    Perl, Andras
    ARTHRITIS RESEARCH & THERAPY, 2014, 16
  • [35] Targeting Regulatory T Cells to Treat Patients With Systemic Lupus Erythematosus
    Mizui, Masayuki
    Tsokos, George C.
    FRONTIERS IN IMMUNOLOGY, 2018, 9
  • [36] Impaired homeostasis of regulatory T cells in patients with systemic lupus erythematosus
    Kataoka, H.
    Kawase, Y.
    Horita, T.
    Yasuda, S.
    Atsumi, T.
    Koike, T.
    ANNALS OF THE RHEUMATIC DISEASES, 2007, 66 : 309 - 309
  • [37] Circulating Angiogenic T Cells and Their Subpopulations in Patients with Systemic Lupus Erythematosus
    Miao, Jinlin
    Qiu, Feng
    Li, Tingting
    Zhao, Peng
    Zhang, Kui
    Lv, Minghua
    Wan, Jun
    Qi, Xiaokun
    Zhu, Ping
    MEDIATORS OF INFLAMMATION, 2016, 2016
  • [38] Characterization of CD3+CD4-CD8- (double negative) T cells in patients with systemic lupus erythematosus:: activation markers
    Anand, A
    Dean, GS
    Quereshi, K
    Isenberg, DA
    Lydyard, PM
    LUPUS, 2002, 11 (08) : 493 - 500
  • [39] Double-negative B cells
    Nicholas J. Bernard
    Nature Reviews Rheumatology, 2018, 14 : 684 - 684
  • [40] Double-negative B cells
    Bernard, Nicholas J.
    NATURE REVIEWS RHEUMATOLOGY, 2018, 14 (12) : 684 - 684