Synthesis, Antitubercular, and Antifungal Activity of 2-(trifluoromethyl)-3-(substituted phenyl-1,3,4-oxadiazol-2-yl)-pyridine

被引：0
|
作者：
Dhotre, B. K. [1 ]
Raut, S. V. [2 ]
Farooqui, M. [2 ]
Jadhav, S. B. [2 ]
Pathan, A. [2 ]
机构：
[1] Swami Vivekanand Sr Coll Mantha, Dept Chem, Mantha, Maharashtra, India
[2] Maulana Azad Coll, Dept Chem, Aurangabad 431001, Maharashtra, India
来源：
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2023年 / 49卷 / SUPPL 1期
关键词：
1,3,4-oxadiazole; pyridine; 2-(trifluoro-methyl)-pyridine-3-carboxylic acid; antitubercular; antifungal; BIOLOGICAL EVALUATION; 1,3,4-OXADIAZOLE DERIVATIVES; ANTIBACTERIAL ACTIVITY; MOLECULAR DOCKING; DESIGN; MOIETY;
D O I：
10.1134/S1068162023080149
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of 2-(trifluoromethyl)-3-(substituted phenyl-1,3,4-oxadiazol-2-yl) pyridine (Va-Vj) was synthesized by reaction of 2-(trifluoromethyl) pyridine-3-carbohydrazide (III) with different substituted benzoic acids (IVa-IVj) in phosphorous oxychloride, obtained compounds were characterized by spectral data. Subsequently, these compounds were tested for their in vitro antifungal activities against C. albicans and A. niger by agar diffusion method, some compounds displayed good antifungal activity when compared with fluconazole. These compounds were also screened for their anti-tubercular activities against primary Mycobacterium smegmatis mc(2) 155. The compounds (Vg) and (Vh) exhibits promising activity with MICs 91 and 109 mu g/mL respectively.
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收藏
页码：S171 / S178
页数：8
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