Genetic and Epigenetic Landscape for Drug Development in Polycystic Ovary Syndrome

被引：1
|
作者：
Chen, Yi [1 ,2 ]
Wang, Guiquan [3 ,4 ]
Chen, Jingqiao [2 ]
Wang, Congying [5 ]
Dong, Xi [1 ]
Chang, Hsun-Ming [6 ]
Yuan, Shuai [7 ,14 ]
Zhao, Yue [8 ,9 ,10 ,11 ,13 ]
Mu, Liangshan [1 ,12 ]
机构：
[1] Fudan Univ, Zhongshan Hosp, Reprod Med Ctr, Shanghai 200032, Peoples R China
[2] Wenzhou Med Univ, Sch Med 1, Wenzhou 325035, Peoples R China
[3] Xiamen Univ, Women & Childrens Hosp, Sch Med, Dept Reprod Med, Xiamen 361003, Peoples R China
[4] Xiamen Univ, Xiamen Key Lab Reprod & Genet, Xiamen 361023, Peoples R China
[5] Zhejiang Univ, Affiliated Hosp 4, Dept Cardiol, Sch Med, Zhejiang 322000, Peoples R China
[6] China Med Univ Hosp, Dept Obstet & Gynecol, Taichung 40400, Taiwan
[7] Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, S-17165 Stockholm, Sweden
[8] Peking Univ Third Hosp, Ctr Reprod Med, Dept Obstet & Gynecol, State Key Lab Female Fertil Promot, Beijing 100191, Peoples R China
[9] Natl Clin Res Ctr Obstet & Gynecol, Beijing 100007, Peoples R China
[10] Peking Univ, Key Lab Assisted Reprod, Minist Educ, Beijing 100191, Peoples R China
[11] Peking Univ, Beijing Key Lab Reprod Endocrinol & Assisted Repro, Beijing 100191, Peoples R China
[12] Fudan Univ, Zhongshan Hosp, Reprod Med Ctr, 180 Fenglin Rd, Shanghai, Peoples R China
[13] Peking Univ Third Hosp, Ctr Reprod Med, Dept Obstet & Gynecol, 49 HuaYuan North Rd, Beijing 100191, Peoples R China
[14] Karolinska Inst, Dept Environm Med, Unit Cardiovasc & Nutr Epidemiol, Nobels Vag 13, S-17165 Solna, Stockholm, Sweden
来源：
ENDOCRINE REVIEWS | 2024年 / 45卷 / 04期
基金：
中国国家自然科学基金;
关键词：
polycystic ovary syndrome; pharmacotherapy; epigenetics; genetics; gene therapy; STIMULATING-HORMONE RECEPTOR; GENOME-WIDE ASSOCIATION; DOUBLE-BLIND; INSULIN-RESISTANCE; DNA METHYLATION; MESSENGER-RNA; MENDELIAN RANDOMIZATION; FOLATE SUPPLEMENTATION; OVULATION INDUCTION; WOMEN;
D O I：
10.1210/endrev/bnae002
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The treatment of polycystic ovary syndrome (PCOS) faces challenges as all known treatments are merely symptomatic. The US Food and Drug Administration has not approved any drug specifically for treating PCOS. As the significance of genetics and epigenetics rises in drug development, their pivotal insights have greatly enhanced the efficacy and success of drug target discovery and validation, offering promise for guiding the advancement of PCOS treatments. In this context, we outline the genetic and epigenetic advancement in PCOS, which provide novel insights into the pathogenesis of this complex disease. We also delve into the prospective method for harnessing genetic and epigenetic strategies to identify potential drug targets and ensure target safety. Additionally, we shed light on the preliminary evidence and distinctive challenges associated with gene and epigenetic therapies in the context of PCOS. Graphical Abstract
引用
收藏
页码：437 / 459
页数：23
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