Microglia C-lectin/selectin' neurons to eat

被引：0
|
作者：
Jiang, Yike [1 ,2 ]
Shinohara, Mari L. [1 ,3 ]
机构：
[1] Duke Univ, Sch Med, Dept Immunol, Durham, NC 27708 USA
[2] Duke Univ, Sch Med, Dept Pediat, Div Pediat Rheumatol, Durham, NC USA
[3] Duke Univ, Sch Med, Dept Mol Genet & Microbiol, Durham, NC 27708 USA
来源：
IMMUNITY | 2023年 / 56卷 / 02期
基金：
美国国家卫生研究院;
关键词：
GLUCOCEREBROSIDASE;
D O I：
10.1016/j.immuni.2023.01.020
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
beta-glucosylceramide (beta-GlcCer) accumulates in Gaucher disease, but how beta-GlcCer, a Mincle ligand, causes characteristic neuroinflammation and neuronopathy is poorly understood. In this issue of Immunity, Shimizu et al. reveal that Mincle-dependent activation of microglia led to phagocytosis of neurons and neurologic symptoms.
引用
收藏
页码：227 / 229
页数：3
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