The role of tumor-infiltrating lymphocytes in triple-negative breast cancer and the research progress of adoptive cell therapy

被引：8
|
作者：
Li, Ruonan [1 ,2 ]
Cao, Lili [1 ,2 ,3 ,4 ]
机构：
[1] Shandong First Med Univ, Affiliated Hosp 1, Oncol Dept, Jinan, Peoples R China
[2] Shandong Prov Qianfoshan Hosp, Jinan, Peoples R China
[3] Shandong Prov Key Lab Rheumat Dis & Translat Med, Jinan, Peoples R China
[4] Shandong Lung Canc Inst, Jinan, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷
关键词：
triple-negative breast cancer (TNBC); tumor-infiltrating lymphocytes (TILs); adoptive cell therapy (ACT); breast cancer; solid tumor; RESPONSES; TISAGENLECLEUCEL; MULTICENTER;
D O I：
10.3389/fimmu.2023.1194020
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The treatment outcome of breast cancer is closely related to estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression. Triple-negative breast cancer (TNBC) lacking ER, PR, and HER2 expression has limited treatment options and a poor prognosis. Tumor-infiltrating lymphocytes (TILs) play a role in promoting or resisting tumors by affecting the tumor microenvironment and are known as key regulators in breast cancer progression. However, treatments for TNBC (e.g., surgery, chemotherapy and radiotherapy) have non-satisfaction's curative effect so far. This article reviews the role of different types of TILs in TNBC and the research progress of adoptive cell therapy, aiming to provide new therapeutic approaches for TNBC.
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页数：9
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