TFEB: a double-edged sword for tumor metastasis

被引：3

作者：

Hu, Jun-Hu ^{[1
,2
,3
]}

Li, Shou-Ye ^{[4
,5
]}

Yu, Li-Hua ^{[1
,2
,3
]}

Guan, Zhen-Rong ^{[1
,2
,3
]}

Jiang, Ya-Ping ^{[1
,2
,3
]}

Hu, Die ^{[1
,2
,3
]}

Wang, Hao-Jie ^{[1
,2
,3
]}

Zhao, Li-Ping ^{[1
,2
,3
]}

Zhou, Zhao-Huang ^{[1
,2
,3
]}

Yan, Ya-Xin ^{[1
,2
,3
]}

Xie, Tian ^{[1
,2
,3
]}

Huang, Zhi-Hui ^{[1
,2
,3
]}

Lou, Jian-Shu ^{[1
,2
,3
]}

机构：

[1] Hangzhou Normal Univ, Sch Pharm, Hangzhou 311121, Zhejiang, Peoples R China

[2] Hangzhou Normal Univ, Collaborat Innovat Ctr Tradit Chinese Med Zhejiang, Key Lab Elemene Class Anticanc Chinese Med, Hangzhou 311121, Zhejiang, Peoples R China

[3] Hangzhou Normal Univ, Collaborat Innovat Ctr Tradit Chinese Med Zhejiang, Engn Lab Dev & Applicat Tradit Chinese Med, Hangzhou 311121, Zhejiang, Peoples R China

[4] Hangzhou Med Coll, Coll Pharm, Hangzhou 311300, Zhejiang, Peoples R China

[5] Zhejiang Eyoung Pharmaceut Res & Dev Ctr, Hangzhou 311258, Zhejiang, Peoples R China

来源：

JOURNAL OF MOLECULAR MEDICINE-JMM | 2023年 / 101卷 / 08期

基金：

中国国家自然科学基金;

关键词：

TFEB; Metastasis; Tumor; Activation; Phosphorylation; PROTEIN-KINASE-C; REGULATING LYSOSOMAL BIOGENESIS; ZIPPER TRANSCRIPTION FACTOR; RENAL-CELL CARCINOMAS; IN-VITRO; AUTOPHAGY; CANCER; CALCINEURIN; EXPRESSION; MITF;

D O I：

10.1007/s00109-023-02337-0

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Transcription factor EB, a member of the microphthalmia-associated transcription factor (MiTF/TFE) family, is a master regulator of autophagy, lysosome biogenesis, and TAMs. Metastasis is one of the main reasons for the failure of tumor therapy. Studies on the relationship between TFEB and tumor metastasis are contradictory. On the positive side, TFEB mainly affects tumor cell metastasis via five aspects, including autophagy, epithelial-mesenchymal transition (EMT), lysosomal biogenesis, lipid metabolism, and oncogenic signaling pathways; on the negative side, TFEB mainly affects tumor cell metastasis in two aspects, including tumor-associated macrophages (TAMs) and EMT. In this review, we described the detailed mechanism of TFEB-mediated regulation of metastasis. In addition, we also described the activation and inactivation of TFEB in several aspects, including the mTORC1 and Rag GTPase systems, ERK2, and AKT. However, the exact process by which TFEB regulates tumor metastasis remains unclear in some pathways, which requires further studies.

引用

页码：917 / 929

页数：13

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