Stereoselective Palladium-Catalyzed C-F Bond Alkenylation of Tetrasubstituted gem-Difluoroalkenes via Mizoroki-Heck Reaction

被引：6
|
作者：
Wang, Yanhui [1 ]
Tsui, Gavin Chit [1 ]
机构：
[1] Chinese Univ Hong Kong, Dept Chem, Hong Kong 999077, Peoples R China
来源：
ORGANIC LETTERS | 2023年
关键词：
VINYLIC FLUORINES; ALKENES; ARYL;
D O I：
10.1021/acs.orglett.3c02452
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly diastereoselectivePd(0)-catalyzed Mizoroki-Heckreaction of gem-difluoroalkenes is described. Unlikepreviously reported C-F bond functionalization with organometallicreagents, this reaction takes place between two different alkenesto achieve a formal C-F and C-H bond cross-couplingvia a distinct pathway. Monofluorinated 1,3-diene products can besynthesized with control of the geometry of each alkene and good functionalgroup tolerability.
引用
收藏
页码：6217 / 6221
页数：5
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