Occupational Exposure to Metal Engineered Nanoparticles: A Human Biomonitoring Pilot Study Involving Italian Nanomaterial Workers

被引:10
|
作者
Bocca, Beatrice [1 ]
Battistini, Beatrice [1 ]
Leso, Veruscka [2 ]
Fontana, Luca [2 ]
Caimi, Stefano [1 ]
Fedele, Mauro [2 ]
Iavicoli, Ivo [2 ]
机构
[1] Ist Super Sanita, Dept Environm & Hlth, I-00161 Rome, Italy
[2] Univ Naples Federico II, Dept Publ Hlth, I-80138 Naples, Italy
关键词
nanomaterials; exposure assessment; biological monitoring; biomarkers; risk assessment; risk management;
D O I
10.3390/toxics11020120
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Advances in nanotechnology have led to an increased use of engineered nanoparticles (ENPs) and the likelihood for occupational exposures. However, how to assess such exposure remains a challenge. In this study, a methodology for human biomonitoring, based on Single Particle Inductively Coupled Plasma Mass Spectrometry (SP-ICP-MS), was developed as a tool to assess the ENPs exposure of workers involved in nanomaterial activities in two Italian Companies. The method was validated for size and number concentration determination of Ag, Au, In2O3, Ir, Pd, Pt, and TiO2 NPs in urine and blood samples. The results showed the presence of In2O3 NPs in blood of exposed workers (mean, 38 nm and 10,371 particles/mL), but not in blood of controls. Silver, Au, and TiO2 NPs were found in urine (mean, Ag 29 nm and 16,568 particles/mL) or blood (mean, Au 15 nm and 126,635 particles/mL; TiO2 84 nm and 27,705 particles/mL) of workers, though these NPs were found also in controls. The presence of ENPs in both workers and controls suggested that the extra-professional exposure is a source of ENPs that cannot be disregarded. Iridium, Pd, and Pt NPs were not detected neither in blood nor in urine. Overall, the findings provided a rational basis to evaluate the exposure assessment to ENPs in cohorts of workers as part of risk assessment and risk management processes in workplaces.
引用
收藏
页数:15
相关论文
共 41 条
  • [32] Pollutants from a plant which burns toxic waste in the Province of Arezzo (Tuscany Region, Central Italy): human biomonitoring pilot study to evaluate the possible type of environmental exposure
    Chellini, Elisabetta
    Fondelli, Maria Cristina
    Maurello, Maria Teresa
    Sciarra, Gianfranco
    Aprea, Maria Cristina
    Carreras, Giulia
    EPIDEMIOLOGIA & PREVENZIONE, 2015, 39 (01): : 28 - 35
  • [33] Occupational exposure to graphene and silica nanoparticles. Part II: pilot study to identify a panel of sensitive biomarkers of genotoxic, oxidative and inflammatory effects on suitable biological matrices
    Ursini, Cinzia Lucia
    Fresegna, Anna Maria
    Ciervo, Aureliano
    Maiello, Raffaele
    Del Frate, Valentina
    Folesani, Giuseppina
    Galetti, Maricla
    Poli, Diana
    Buresti, Giuliana
    Di Cristo, Luisana
    Sabella, Stefania
    Iavicoli, Sergio
    Cavallo, Delia
    NANOTOXICOLOGY, 2021, 15 (02) : 223 - 237
  • [34] Study of occupational exposure to brick kiln emissions on heavy metal burden, biochemical profile, cortisol level and reproductive health risks among female workers at Rawat, Pakistan
    David, Mehwish
    Qurat-Ul-Ain
    Afzal, Muhammad
    Shoaib, Muhammad
    Aman, Faiza
    Cloete, Karen J.
    Turi, Naheed
    Jahan, Sarwat
    ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 2020, 27 (35) : 44073 - 44088
  • [35] Study of occupational exposure to brick kiln emissions on heavy metal burden, biochemical profile, cortisol level and reproductive health risks among female workers at Rawat, Pakistan
    Mehwish David
    Muhammad Qurat-Ul-Ain
    Muhammad Afzal
    Faiza Shoaib
    Karen J. Aman
    Naheed Cloete
    Sarwat Turi
    Environmental Science and Pollution Research, 2020, 27 : 44073 - 44088
  • [36] Metal and oxidative potential exposure through particle inhalation and oxidative stress biomarkers: a 2-week pilot prospective study among Parisian subway workers
    Jean-Jacques Sauvain
    Maud Hemmendinger
    Thomas Charreau
    Valérie Jouannique
    Amélie Debatisse
    Guillaume Suárez
    Nancy B. Hopf
    Irina Guseva Canu
    International Archives of Occupational and Environmental Health, 2024, 97 : 387 - 400
  • [37] Metal and oxidative potential exposure through particle inhalation and oxidative stress biomarkers: a 2-week pilot prospective study among Parisian subway workers
    Sauvain, Jean-Jacques
    Hemmendinger, Maud
    Charreau, Thomas
    Jouannique, Valerie
    Debatisse, Amelie
    Suarez, Guillaume
    Hopf, Nancy B.
    Guseva Canu, Irina
    INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH, 2024, 97 (04) : 387 - 400
  • [38] Exposure to airborne iron oxide nanoparticles induces oxidative DNA damage and inflammatory responses: a pilot study in welders and in human lung epithelial cell line
    Thanachoksawang, Chatchai
    Navasumrit, Panida
    Hunsonti, Potchanee
    Chompoobut, Chalida
    Chaisatra, Krittinee
    Autrup, Herman
    Ruchirawat, Mathuros
    TOXICOLOGY AND ENVIRONMENTAL HEALTH SCIENCES, 2022, 14 (04) : 339 - 349
  • [39] Exposure to airborne iron oxide nanoparticles induces oxidative DNA damage and inflammatory responses: a pilot study in welders and in human lung epithelial cell line
    Chatchai Thanachoksawang
    Panida Navasumrit
    Potchanee Hunsonti
    Chalida Chompoobut
    Krittinee Chaisatra
    Herman Autrup
    Mathuros Ruchirawat
    Toxicology and Environmental Health Sciences, 2022, 14 : 339 - 349
  • [40] Particle Background Levels In Human TissuesPABALIHT project. Part I: a nanometallomic study of metal-based micro- and nanoparticles in liver and kidney in an Italian population group
    Locci, Emanuela
    Pilia, Ilaria
    Piras, Roberto
    Pili, Sergio
    Marcias, Gabriele
    Cocco, Pierluigi
    De Giorgio, Fabio
    Bernabei, Manuele
    Brusadin, Valentina
    Allegrucci, Laura
    Bandiera, Alessandra
    d'Aloja, Ernesto
    Sabbioni, Enrico
    Campagna, Marcello
    JOURNAL OF NANOPARTICLE RESEARCH, 2019, 21 (03)