Synthesis and Phosphonylation of 6-Methyl-4-aryl-2-thio-1,2,3,4-tetrahydropyrimidine-5-carboxylic Acids Ethyl Esters

被引：2

作者：

Nosova, N. A. ^{[1
]}

Skrylkova, A. S. ^{[2
]}

Egorov, D. M. ^{[2
]}

机构：

[1] St Petersburg State Chem Pharmaceut Univ, St Petersburg 197376, Russia

[2] Tech Univ, St Petersburg State Technol Inst, St Petersburg 190013, Russia

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2023年 / 93卷 / 09期

关键词：

Biginelli reaction; phosphonylation; thiazolo[3,2-a]pyrimidine; 2-thio-1,2,3,4-tetrahydropyrimidine; BIOLOGICAL-ACTIVITY; DERIVATIVES;

D O I：

10.1134/S1070363223090062

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new series of 6-methyl-4-aryl-2-thio-1,2,3,4-tetrahydropyrimidine-5-carboxylic acids ethyl esters was synthesized. The reaction of the obtained esters with dimethyl 2-chloroethynylphosphonate leads to the selective formation of new ethyl 3-(dimethoxyphosphoryl)-5-aryl-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylates.

引用

页码：2230 / 2236

页数：7

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