The Main Therapeutic Applications of Cannabidiol (CBD) and Its Potential Effects on Aging with Respect to Alzheimer's Disease

被引：2
|
作者：
Trojan, Vaclav [1 ]
Landa, Leos [1 ,2 ]
Sulcova, Alexandra [1 ]
Sliva, Jiri [3 ]
Hrib, Radovan [1 ,4 ]
机构：
[1] St Annes Univ Hosp, Int Clin Res Ctr, Cannabis Facil, Pekarska 53, Brno 60200, Czech Republic
[2] Masaryk Univ, Fac Med, Dept Pharmacol, Kamenice 5, Brno 62500, Czech Republic
[3] Charles Univ Prague, Fac Med 3, Dept Pharmacol, Ruska 87, Prague 10000, Czech Republic
[4] St Annes Univ Hosp, Ctr Pain Management, Dept Anesthesiol & Intens Care, Pekarska 53, Brno 60200, Czech Republic
来源：
BIOMOLECULES | 2023年 / 13卷 / 10期
关键词：
cannabidiol; aging; Alzheimer's disease; cannabinoids; ENDOCANNABINOID SYSTEM; MEDICAL CANNABIS; DRUG; INHIBITOR; UPDATE; TARGET; SAFETY; UCM707; TRIAL;
D O I：
10.3390/biom13101446
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The use of cannabinoids (substances contained specifically in hemp plants) for therapeutic purposes has received increased attention in recent years. Presently, attention is paid to two main cannabinoids: delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). With respect to the psychotropic effects and dependence potential of THC (though it is very mild), its use is associated with certain restrictions, and thus the therapeutic properties of CBD are frequently emphasized because there are no limitations associated with the risk of dependence. Therefore, this review covers the main pharmacodynamic and pharmacokinetic features of CBD (including characteristics of endocannabinoidome) with respect to its possible beneficial effects on selected diseases in clinical practice. A substantial part of the text deals with the main effects of CBD on aging, including Alzheimer's disease and related underlying mechanisms.
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页数：13
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