Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease

被引：26
|
作者：
Caraci, Filippo [1 ,2 ]
Nicoletti, Ferdinando [3 ,4 ]
Copani, Agata [1 ,5 ]
机构：
[1] Univ Catania, Dept Drug Sci, Catania, Italy
[2] Oasi Inst Res Mental Retardat & Brain Aging IRCCS, Troina, Italy
[3] Univ Rome Sapienza, Dept Physiol & Pharmacol, Rome, Italy
[4] Neuromed IRCCS, Pozzilli, Italy
[5] CNR, Inst Biostruct & Bioimaging, Catania, Italy
来源：
CURRENT OPINION IN PHARMACOLOGY | 2018年 / 38卷
关键词：
CELLULAR PRION PROTEIN; CENTRAL-NERVOUS-SYSTEM; AMYLOID-BETA OLIGOMERS; LONG-TERM DEPRESSION; A-BETA; MOUSE MODEL; ALLOSTERIC MODULATION; COGNITIVE IMPAIRMENT; RAT HIPPOCAMPUS; CEREBRAL-CORTEX;
D O I：
10.1016/j.coph.2017.12.001
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A dysfunction of glutamate signaling is implicated at several levels in the pathogenesis of Alzheimer's disease. Currently, metabotropic glutamate receptors, which have a wide distribution in the central nervous system and activate a multitude of cell signaling pathways, are pursued as targets for therapeutic intervention in Alzheimer's disease. Research is still limited, but results underscore the relevance of ongoing studies. Here we discuss the latest updates regarding metabotropic glutamate receptors and their role in Alzheimer's disease, as well as promising metabotropic glutamate receptor ligands that have been investigated in preclinical models of Alzheimer's disease.
引用
收藏
页码：1 / 7
页数：7
相关论文
共 50 条
  • [1] Therapeutic potential of targeting metabotropic glutamate receptors for Parkinson's disease
    Dickerson, Jonathan W.
    Conn, P. Jeffrey
    [J]. NEURODEGENERATIVE DISEASE MANAGEMENT, 2012, 2 (02) : 221 - 232
  • [2] The role of metabotropic glutamate receptors in Alzheimer's disease
    Lee, H
    Zhu, XW
    O'Neill, MJ
    Webber, K
    Casadesus, G
    Marlatt, M
    Raina, AK
    Perry, G
    Smith, MA
    [J]. ACTA NEUROBIOLOGIAE EXPERIMENTALIS, 2004, 64 (01) : 89 - 98
  • [3] Allosteric Modulators of Metabotropic Glutamate Receptors as Promising Therapeutic Strategies for Alzheimer's Disease
    Rook, Jerri M.
    Dickerson, Jonathan W.
    Ghoshal, Ayan
    Walker, Adam G.
    Roop, Gregory N.
    Huan, Qiuwei
    Stauffer, Shaun R.
    Niswender, Colleen M.
    Daniels, J. Scott
    Jones, Carrie K.
    Lindsley, Craig W.
    Conn, P. Jeffrey
    [J]. CURRENT NEUROPHARMACOLOGY, 2014, 12 : 53 - 53
  • [4] The Implication of Glial Metabotropic Glutamate Receptors in Alzheimer's Disease
    de Lima, Izabella B. Q.
    Ribeiro, Fabiola M.
    [J]. CURRENT NEUROPHARMACOLOGY, 2023, 21 (02) : 164 - 182
  • [5] The Role of Neuroglial Metabotropic Glutamate Receptors in Alzheimer's Disease
    Abd-Elrahman, Khaled S.
    Sarasija, Shaarika
    Ferguson, Stephen S. G.
    [J]. CURRENT NEUROPHARMACOLOGY, 2023, 21 (02) : 273 - 283
  • [6] Metabotropic Glutamate Receptors in Alzheimer's Disease Synaptic Dysfunction: Therapeutic Opportunities and Hope for the Future
    Srivastava, Akriti
    Das, Brati
    Yao, Annie Y.
    Yan, Riqiang
    [J]. JOURNAL OF ALZHEIMERS DISEASE, 2020, 78 (04) : 1345 - 1361
  • [7] Metabotropic glutamate receptors as therapeutic targets in Parkinson's disease
    Reynolds, I. J.
    [J]. NEUROPHARMACOLOGY, 2008, 55 (04) : 620 - 621
  • [8] Therapeutic potential of targeting group III metabotropic glutamate receptors in the treatment of Parkinson's disease
    Duty, Susan
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 2010, 161 (02) : 271 - 287
  • [9] Physiological roles and therapeutic potential of metabotropic glutamate receptors
    Conn, PJ
    [J]. GLUTAMATE AND DISORDERS OF COGNITION AND MOTIVATION, 2003, 1003 : 12 - 21
  • [10] Therapeutic potential of group III metabotropic glutamate receptors
    Lavreysen, Hilde
    Dautzenberg, Frank M.
    [J]. CURRENT MEDICINAL CHEMISTRY, 2008, 15 (07) : 671 - 684
12345