Predictors of persistent post-surgical pain intensity and interference at 1 year after breast cancer surgery: assessing central sensitization, central sensitivity symptoms, and psychological factors

被引：6
|
作者：
Manfuku, Masahiro [1 ,2 ]
Nishigami, Tomohiko [3 ]
Mibu, Akira [4 ]
Yamashita, Hirofumi [5 ]
Imai, Ryota [6 ]
Kanamori, Hiroe [7 ]
Sumiyoshi, Kazuhiro [7 ]
机构：
[1] Breast Care Sensyu Clin, Dept Rehabil, Osaka, Japan
[2] Prefectural Univ Hiroshima, Grad Sch Comprehens Sci Res, Hiroshima, Japan
[3] Prefectural Univ Hiroshima, Fac Hlth & Welf, Dept Phys Therapy, Mihara, Hiroshima, Japan
[4] Konan Womens Univ, Dept Phys Therapy, Kobe, Hyogo, Japan
[5] Dept Rehabil, Nozomi Orthopaed Clin Saijo, Hiroshima, Japan
[6] Osaka Kawasaki Rehabil Univ, Grad Sch Rehabil, Osaka, Japan
[7] Breast Care Sensyu Clin, Dept Breast Surg, Osaka, Japan
来源：
BREAST CANCER | 2023年 / 30卷 / 02期
关键词：
Breast cancer survivors; Persistent post-surgical pain; Post mastectomy pain syndrome; Central sensitization; Central sensitivity symptoms; INVENTORY; METAANALYSIS; SEVERITY; UTILITY;
D O I：
10.1007/s12282-022-01420-7
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background Persistent post-surgical pain (PPSP) is associated with upper limb dysfunction and decreased quality of life and causes long-term suffering for breast cancer survivors after surgery. However, the predictors of PPSP remain unclear. The purpose of this study was to examine predictors of PPSP intensity and interference at 1 year postoperatively, focusing on treatment-related factors, pre- and postoperative central sensitization (CS), CS-related symptoms (e.g., muscle stiffness, fatigue, sleep disturbances), and psychological factors.Methods Eighty-eight women with planned unilateral breast cancer surgery were included in this longitudinal study. CS, CS-related symptoms, and psychological factors were assessed preoperatively, 1 month postoperatively, and 1 year postoperatively. Analysis of covariance was used to compare the groups with and without PPSP, accounting for treatment-related factors. Multiple regression analysis was performed to identify predictors of PPSP intensity and interference at 1 year postoperatively.Results Even after adjusting for covariates, preoperative and 1-month postoperative Central Sensitization Inventory scores in the PPSP group were significantly higher than scores in the group without PPSP. Multiple regression analysis showed that axillary lymph node dissection (ALND) and 1-month postoperative CS-related symptoms were independent predictors of PPSP intensity and interference at 1 year postoperatively (p < 0.01).Conclusion We found that ALND and 1-month postoperative CS-related symptoms were predictors of PPSP intensity and interference at 1 year postoperatively.
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页码：271 / 281
页数：11
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