Anti-Trichomonas vaginalis activity of essential oils extracted from Caatinga Myrtaceae species and chemical composition of Eugenia pohliana DC.

被引：2

作者：

de Menezes, Saulo Almeida ^{[1
,2
,3
]}

Galego, Giulia Bongiorni ^{[2
,3
]}

Rigo, Graziela de Vargas ^{[2
,3
]}

Farias de Aguiar, Julio Cesar Ribeiro de Oliveira ^{[4
]}

Veras, Bruno de Oliveira ^{[1
]}

Sombra Vandesmet, Lilian Cortez ^{[1
]}

Bezerra dos Santos, Cicero Ramon ^{[1
]}

Vidal Sampaio, Mariana Gomes ^{[1
]}

Marques, Clecia de Carvalho ^{[1
]}

Lermen, Vilmar Luiz ^{[5
]}

Ferraz Navarro, Daniela Maria do Amaral ^{[4
]}

da Silva, Marcia Vanusa ^{[1
,6
]}

dos Santos Correia, Maria Tereza ^{[1
,6
]}

Tasca, Tiana ^{[2
,3
]}

机构：

[1] Univ Fed Pernambuco, Ctr Biociencias, Dept Bioquim, Lab Prod Nat, Recife, PE, Brazil

[2] Univ Fed Rio Grande do Sul, Fac Farm, Grp Pesquisa Tricomonas, Porto Alegre, RS, Brazil

[3] Univ Fed Rio Grande do Sul, Ctr Biotecnol, Porto Alegre, RS, Brazil

[4] Univ Fed Pernambuco, Dept Quim Fundamental, Ctr Ciencias Exatas & Nat, Recife, PE, Brazil

[5] Comunidade Serra Paus Doias, Chapada Do Araripe, Exu, Brazil

[6] Inst Nacl Semiarido, Nucleo Bioprospeccao & Conservacao Caatinga, Campina Grande, Paraiba, Brazil

来源：

NATURAL PRODUCT RESEARCH | 2023年 / 37卷 / 06期

关键词：

Trichomoniasis; Trichomonas vaginalis; essential oil; Myrtaceae; Caatinga;

D O I：

10.1080/14786419.2022.2101050

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The current trichomoniasis treatment is restrict to 5-nitroimidazole drugs and the emergence of resistant isolates points the need for new therapeutical alternatives. In this study the anti-Trichomonas vaginalis activity of essential oils obtained from Myrtaceae occurring in Caatinga, a plant family with potential antiparasitic activity, was showed. The essential oils varied in their capacity to kill ATCC and fresh clinical T. vaginalis isolates, which was associated with heterogeneity and different patterns of endosymbiosis. Essential oils caused moderate to strong cytotoxicity against mammalian cells, but essential oil of Eugenia pohliana (EOEp) exhibited promising selectivity index towards vaginal epithelial cells. A checkerboard assay revealed a synergistic effect when EOEp and metronidazole were associated, indicating different mechanisms of action. The GC/MS analysis demonstrated the volatile composition of EOEp, with delta-cadinene as majoritary component. This molecule seems to contribute to the trichomonacidal effect and shows potential for the prospection of new antiparasitic compounds.

引用

页码：1042 / 1046

页数：5

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