Hepatocellular Carcinoma Rupture after Introducing Lenvatinib: An Autopsy Case Report

被引：0

作者：

Kohya, Risako ^{[1
]}

Sugiura, Ryo ^{[1
,2
,3
]}

Yamamoto, Yoshiya ^{[1
]}

Naruse, Hirohito ^{[1
]}

Hatanaka, Kazuteru ^{[1
]}

Kinoshita, Kenji ^{[1
]}

Abiko, Satoshi ^{[1
]}

Miyamoto, Shuichi ^{[1
]}

Suzuki, Kazuharu ^{[1
]}

Kushibiki, Hanae ^{[4
]}

Munakata, Satoru ^{[4
]}

Shimoyama, Norihiko ^{[4
]}

机构：

[1] Hakodate Municipal Hosp, Dept Gastroenterol & Hepatol, Hakodate, Japan

[2] Hokkaido Univ, Dept Gastroenterol & Hepatol, Fac Med, Sapporo, Japan

[3] Grad Sch Med, Tokyo, Japan

[4] Hakodate Municipal Hosp, Dept Pathol, Hakodate, Japan

来源：

INTERNAL MEDICINE | 2023年 / 62卷 / 07期

关键词：

adverse effect; autopsy case; hepatocellular carcinoma; lenvatinib;

D O I：

10.2169/internalmedicine.0114-22

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hepatocellular carcinoma (HCC) hemorrhaging/rupture is a rare adverse effect of lenvatinib, and only limited pathological examinations have been reported. This report presents the case of a 69-year-old man who suffered from cardiac arrest and died 7 days after starting lenvatinib treatment for HCC, with an autopsy subsequently performed. Crack and coagulated blood were observed in the largest tumor. Pathologically, the hemorrhaging area was scattered in nearly all of the HCC lesions, regardless of tumor differentiation. This pathological feature is unusual in normal HCC. Thus, it is believed to have been the effect of lenvatinib.

引用

页码：995 / 998

页数：4

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