Red blood cells in biology and translational medicine: natural vehicle inspires new biomedical applications

被引：0

作者：

Zhang, Xueyun ^{[1
,2
,3
]}

Lin, Yindan ^{[1
,3
]}

Xin, Jinxia ^{[1
,4
]}

Zhang, Ying ^{[1
,4
]}

Yang, Kaiwen ^{[6
]}

Luo, Yan ^{[2
,3
]}

Wang, Ben ^{[1
,4
,5
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 2, Key Lab Canc Prevent & Intervent, China Natl Minist Educ,Canc Inst,Sch Med, Hangzhou 310009, Peoples R China

[2] Zhejiang Univ, Sch Med, Dept Biochem, Hangzhou 310058, Peoples R China

[3] Zhejiang Univ, Affiliated Hosp 4, Int Inst Med, Dept Biochem & Canc Med,Sch Med, Yiwu, Zhejiang, Peoples R China

[4] Zhejiang Univ, Inst Translat Med, Hangzhou 310029, Peoples R China

[5] Zhejiang Univ, Canc Ctr, Hangzhou 310029, Peoples R China

[6] Hon Hai Precis Ind Co Ltd, New Taipei, Taiwan

来源：

THERANOSTICS | 2024年 / 14卷 / 01期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

cell surface engineering; cell therapy; drug delivery; red blood cells; universal blood; HEMATOPOIETIC STEM-CELLS; UNIVERSAL DONOR BLOOD; SIALIC-ACID; DRUG-DELIVERY; GLYCOPHORIN-A; EX-VIVO; SENESCENT ERYTHROCYTES; CHROMOSOMAL LOCATIONS; MOLECULAR-MECHANISMS; ALPHA-GALACTOSIDASE;

D O I：

10.7150/thno.87425

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Red blood cells (RBCs) are the most abundant cell type in the blood, and play a critical role in oxygen transport. With the development of nanobiotechnology and synthetic biology, scientists have found multiple ways to take advantage of the characteristics of RBCs, such as their long circulation time, to construct universal RBCs, develop drug delivery systems, and transform cell therapies for cancer and other diseases. This article reviews the component and aging mystery of RBCs, the methods for the applied universal RBCs, and the application prospects of RBCs, such as the engineering modification of RBCs used in cytopharmaceuticals for drug delivery and immunotherapy. Finally, we summarize some perspectives on the biological features of RBCs and provide further insights into translational medicine.

引用

页码：220 / 248

页数：29

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