Towards a Global View of Parkinson's Disease Genetics

被引：3
|
作者：
Khani, Marzieh [2 ,3 ]
Cerquera-Cleves, Catalina [4 ,5 ]
Kekenadze, Mariam [6 ,7 ]
Crea, Peter Wild [2 ,3 ]
Singleton, Andrew B. [2 ,3 ]
Bandres-Ciga, Sara [1 ,2 ,3 ]
机构：
[1] NIA, NIH, Ctr Alzheimers Dis & Related Dementias CARD, 9000 Rockville Pike,NIH Bldg T44, Bethesda, MD 20892 USA
[2] NIA, Ctr Alzheimers & Related Dementias CARD, Bethesda, MD USA
[3] NINDS, NIH, Bethesda, MD USA
[4] Pontificia Univ Javeriana, San Ignacio Hosp, Neurol Unit, Bogota, Colombia
[5] Laval Univ, CHU Quebec Res Ctr, Axe Neurosci, Quebec City, PQ, Canada
[6] Tbilisi State Med Univ, Tbilisi, Georgia
[7] UCL, Queen Sq Inst Neurol, London, England
来源：
ANNALS OF NEUROLOGY | 2024年 / 95卷 / 05期
基金：
美国国家卫生研究院;
关键词：
ALPHA-SYNUCLEIN; LRRK2; G2019S; GLUCOCEREBROSIDASE MUTATIONS; ASHKENAZI JEWS; PENETRANCE; RISK; PHENOTYPE; FREQUENCY; VPS35; DUPLICATION;
D O I：
10.1002/ana.26905
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Parkinson's disease (PD) is a global health challenge, yet historically studies of PD have taken place predominantly in European populations. Recent genetics research conducted in non-European populations has revealed novel population-specific genetic loci linked to PD risk, highlighting the importance of studying PD globally. These insights have broadened our understanding of PD etiology, which is crucial for developing disease-modifying interventions. This review comprehensively explores the global genetic landscape of PD, emphasizing the scientific rationale for studying underrepresented populations. It underscores challenges, such as genotype-phenotype heterogeneity and inclusion difficulties for non-European participants, emphasizing the ongoing need for diverse and inclusive research in PD. ANN NEUROL 2024
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页码：831 / 842
页数：12
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