Efficacy and Safety of XEN1101, a Novel Potassium Channel Opener, in Adults With Focal Epilepsy

被引：16

作者：

French, Jacqueline A. ^{[1
,8
]}

Porter, Roger J. ^{[2
]}

Perucca, Emilio ^{[3
,4
]}

Brodie, Martin J. ^{[5
]}

Rogawski, Michael A. ^{[6
]}

Pimstone, Simon ^{[7
]}

Aycardi, Ernesto ^{[7
]}

Harden, Cynthia ^{[7
]}

Qian, Jenny ^{[7
]}

Luzon Rosenblut, Constanza ^{[7
]}

Kenney, Christopher ^{[7
]}

Beatch, Gregory N. ^{[7
]}

机构：

[1] NYU, Comprehens Epilepsy Ctr, New York, NY USA

[2] Univ Penn, Dept Neurol, Philadelphia, PA USA

[3] Univ Melbourne, Austin Hlth, Dept Med, Melbourne, Vic, Australia

[4] Monash Univ, Dept Neurosci, Melbourne, Vic, Australia

[5] Western Infirm & Associated Hosp, Univ Dept Med & Therapeut, Glasgow, Scotland

[6] Univ Calif Davis, Sch Med, Sacramento, CA USA

[7] Xenon Pharmaceut, Vancouver, BC, Canada

[8] NYU, Comprehens Epilepsy Ctr, 223 34th St, New York, NY 10016 USA

来源：

JAMA NEUROLOGY | 2023年 / 80卷 / 11期

关键词：

D O I：

10.1001/jamaneurol.2023.3542

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

QuestionIs the novel Kv7.2/Kv7.3 potassium channel opener XEN1101 effective in reducing the monthly seizure frequency in adults experiencing focal-onset seizures (FOSs) despite treatment with 1 to 3 baseline antiseizure medications (ASMs)?FindingsIn this phase 2b randomized clinical trial including 325 patients with FOSs, treatment with XEN1101 was associated with a statistically significant and robustly dose-dependent decrease in monthly seizure frequency and was generally well tolerated, with adverse effects similar to those of currently available ASMs.MeaningThe findings of this trial support the continued development of XEN1101 for the treatment of FOSs.

引用

页码：1145 / 1154

页数：10

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