Synthesis of imidazo[1,2-a]pyridine-containing peptido- mimetics by tandem of Groebke-Blackburn-Bienayme and Ugi reactions

被引：5

作者：

Kolomiiets, Oleksandr, V ^{[1
,2
]}

Tsygankov, Alexander, V ^{[1
,3
]}

Kornet, Maryna N. ^{[4
]}

Brazhko, Aleksander A. ^{[4
]}

Musatov, Vladimir I. ^{[1
]}

Chebanov, Valentyn A. ^{[1
,2
]}

机构：

[1] Natl Acad Sci Ukraine, State Sci Inst Inst Single Crystals, Div Chem Funct Mat, Nauky Ave, 60, UA-61072 Kharkiv, Ukraine

[2] Kharkov Natl Univ, Fac Chem, Svobody Sq, 4, UA-61022 Kharkiv, Ukraine

[3] Natl Tech Univ, Kharkiv Polytech Inst, Kyrpychova st, 2, UA-61002 Kharkiv, Ukraine

[4] Zaporizhzhya Natl Univ, Lab Biotechnol Physiol Act Subst, Zhukovsky Str 66, UA-69600 Zaporizhzhya, Ukraine

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 19卷

基金：

新加坡国家研究基金会;

关键词：

Groebke-Blackburn-Bienayme reaction; imidazo[1; 2-a]pyridine; isocyanide; multicomponent reaction; peptidomimetic; Ugi reaction; MULTICOMPONENT REACTION; RECEPTOR; DERIVATIVES; DISCOVERY; PYRAZINES; BINDING;

D O I：

10.3762/bjoc.19.53

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Peptidomimetics with a substituted imidazo[1,2-a ]pyridine fragment were synthesized by a tandem of Groebke-Black-burn-Bienayme and Ugi reactions. The target products contain substituted imidazo[1,2-a]pyridine and peptidomimetic moieties as pharmacophores with four diversity points introduced from readily available starting materials, including scaffold diversity. A small focused compound library of 20 Ugi products was prepared and screened for antibacterial activity.

引用

页码：727 / 735

页数：9

共 49 条

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