Exposure to polycyclic aromatic hydrocarbons, volatile organic compounds, and tobacco-specific nitrosamines and incidence of esophageal cancer

被引：1

作者：

Etemadi, Arash ^{[1
,2
,12
]}

Poustchi, Hossein ^{[3
]}

Chang, Cindy M. ^{[4
]}

Calafat, Antonia M. ^{[5
]}

Blount, Benjamin C. ^{[5
]}

Bhandari, Deepak ^{[5
]}

Wang, Lanqing ^{[5
]}

Roshandel, Gholamreza ^{[6
]}

Alexandridis, Apostolos ^{[4
]}

Botelho, Julianne Cook ^{[5
]}

Xia, Baoyun ^{[5
]}

Wang, Yuesong ^{[5
]}

Sosnoff, Connie S. ^{[5
]}

Feng, Jun ^{[5
]}

Nalini, Mahdi ^{[1
]}

Khoshnia, Masoud ^{[6
]}

Pourshams, Akram ^{[2
]}

Sotoudeh, Masoud ^{[2
]}

Gail, Mitchell H. ^{[7
]}

Dawsey, Sanford M. ^{[1
]}

Kamangar, Farin ^{[8
]}

Boffetta, Paolo ^{[9
,10
]}

Brennan, Paul ^{[11
]}

Abnet, Christian C. ^{[1
]}

Malekzadeh, Reza ^{[2
]}

Freedman, Neal D. ^{[1
]}

机构：

[1] NCI, Metab Epidemiol Branch, Div Canc Epidemiol & Genet, NIH, Bethesda, MD USA

[2] Univ Tehran Med Sci, Digest Dis Res Inst, Digest Oncol Res Ctr, Tehran, Iran

[3] Univ Tehran Med Sci, Digest Dis Res Inst, Liver & Pancreaticobilliary Res Ctr, Tehran, Iran

[4] US FDA, Ctr Tobacco Prod, Silver Spring, MD USA

[5] CDCP, Div Lab Sci, Natl Ctr Environm Hlth, Atlanta, GA USA

[6] Golestan Univ Med Sci, Golestan Res Ctr Gastroenterol & Hepatol, Gorgan, Iran

[7] NCI, Biostat Branch, Div Canc Epidemiol & Genet, NIH, Bethesda, MD USA

[8] Morgan State Univ, Sch Comp Math & Nat Sci, Dept Biol, Baltimore, MD USA

[9] SUNY Stony Brook, Stony Brook Canc Ctr, Stony Brook, NY USA

[10] Univ Bologna, Dept Med & Surg Sci, Bologna, Italy

[11] Int Agcy Res Canc, Lyon, France

[12] NCI, Div Canc Epidemiol & Genet, 9609 Med Ctr Dr, Rockville, MD 20850 USA

来源：

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE | 2024年 / 116卷 / 03期

关键词：

NEVER SMOKERS; HIGH-RISK; BIOMARKERS; METABOLITES; CARCINOGENS; TISSUE; AREA;

D O I：

10.1093/jnci/djad218

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background Studying carcinogens in tobacco and nontobacco sources may be key to understanding the pathogenesis and geographic distribution of esophageal cancer.Methods The Golestan Cohort Study has been conducted since 2004 in a region with high rates of esophageal squamous cell carcinoma. For this nested study, the cases comprised of all incident cases by January 1, 2018; controls were matched to the case by age, sex, residence, time in cohort, and tobacco use. We measured urinary concentrations of 33 exposure biomarkers of nicotine, polycyclic aromatic hydrocarbons, volatile organic compounds, and tobacco-specific nitrosamines. We used conditional logistic regression to calculate odds ratios (ORs) and 95% confidence intervals for associations between the 90th vs the 10th percentiles of the biomarker concentrations and incident esophageal squamous cell carcinoma.Results Among individuals who did not currently use tobacco (148 cases and 163 controls), 2 acrolein metabolites, 2 acrylonitrile metabolites, 1 propylene oxide metabolite, and one 1,3-butadiene metabolite were significantly associated with incident esophageal squamous cell carcinoma (adjusted odds ratios between 1.8 and 4.3). Among tobacco users (57 cases and 63 controls), metabolites of 2 other volatile organic compounds (styrene and xylene) were associated with esophageal squamous cell carcinoma (OR = 6.2 and 9.0, respectively). In tobacco users, 2 tobacco-specific nitrosamines (NNN and N'-Nitrosoanatabine) were also associated with esophageal squamous cell carcinoma. Suggestive associations were seen with some polycyclic aromatic hydrocarbons (especially 2-hydroxynaphthalene) in nonusers of tobacco products and other tobacco-specific nitrosamines in tobacco users.Conclusion These novel associations based on individual-level data and samples collected many years before cancer diagnosis, from a population without occupational exposure, have important public health implications.

引用

页码：379 / 388

页数：10

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