The Utilization of Low Dose Naltrexone for Chronic Pain

被引：1

作者：

Poliwoda, Salomon ^{[1
]}

Noss, Bryant ^{[2
]}

Truong, Gia Thinh D. ^{[2
]}

Creech, Zachary A. ^{[2
]}

Koushik, Sarang S. ^{[3
]}

Urits, Ivan ^{[4
,5
]}

Viswanath, Omar ^{[6
,7
,8
]}

机构：

[1] Mt Sinai Med Ctr, Dept Anesthesiol, 4300 Alton Rd, Miami Beach, FL 33140 USA

[2] Creighton Univ, Sch Med Phoenix, Phoenix, AZ USA

[3] Creighton Univ, Valleywise Hlth Med Ctr, Dept Anesthesiol & Pain Med, Sch Med Phoenix, Phoenix, AZ USA

[4] Louisiana State Univ Hlth Shreveport, Dept Anesthesiol, Shreveport, LA USA

[5] Southcoast Hlth Pain Management, Southcoast Hlth Phys Grp, Wareham, MA USA

[6] Innovat Pain & Wellness, Scottsdale, AZ USA

[7] Louisiana State Univ, Dept Anesthesiol, Hlth Sci Ctr Shreveport, Shreveport, LA USA

[8] Creighton Univ, Dept Anesthesiol, Sch Med, Phoenix, AZ USA

来源：

CNS DRUGS | 2023年 / 37卷 / 08期

关键词：

CONTROLLED-TRIAL; CROHNS-DISEASE; PILOT TRIAL; FIBROMYALGIA; ANTAGONISTS; MANAGEMENT; SAFETY; METABOLISM; DEPENDENCE; ANALGESIA;

D O I：

10.1007/s40263-023-01018-3

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Naltrexone is a mu-opioid receptor antagonist with a long half-life compared with naloxone. Both of these drugs, along with others, were developed with the intention of reversing the effects of opioid abuse or toxicity. Evidence has also shown that naltrexone has a benefit in preventing relapse by reducing opioid cravings and reducing symptoms of opioid withdrawal. The benefits of this drug were not only shown with opioid abuse. In 1984 this drug was also approved for alcohol abuse. Naltrexone has been proven to decrease alcohol relapse by decreasing the craving. Apart from these approved indications for the use of naltrexone, with time, it has been seen that this drug has a benefit in treating chronic pain. A number of studies have shown the benefits of this drug with inflammatory bowel disease, fibromyalgia, multiple sclerosis, diabetic neuropathy, and complex regional pain syndrome, among others. More studies are needed to approve this medication for specific chronic pain conditions.

引用

页码：663 / 670

页数：8

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