Risk of primary haematologic cancers following incident non-metastatic breast cancer: A Danish population-based cohort study

被引:0
|
作者
Hjorth, Cathrine F. [1 ,2 ,7 ]
Farkas, Dora K. [1 ,2 ]
Schapira, Lidia [3 ,4 ]
Cullen, Mark R. [4 ,5 ]
Sorensen, Henrik T. [1 ,2 ,6 ]
Cronin-Fenton, Deirdre [1 ,2 ]
机构
[1] Aarhus Univ Hosp, Dept Clin Epidemiol, Dept Clin Med, Aarhus, Denmark
[2] Aarhus Univ, Aarhus, Denmark
[3] Stanford Univ, Stanford Canc Inst, Stanford, CA USA
[4] Stanford Univ, Dept Med, Stanford, CA USA
[5] Stanford Univ, Stanford Ctr Populat Hlth Sci, Stanford, CA USA
[6] Stanford Univ, Stanford Clin Excellence Res Ctr, Stanford, CA USA
[7] Olof Palmes Alle 43-45, DK-8200 Aarhus N, Denmark
关键词
Breast neoplasm; Neoplasms; Second Primary; Haematologic diseases; Chemically-induced; disorders; ACUTE MYELOID-LEUKEMIA; COOPERATIVE GROUP DBCG; RADIATION-THERAPY; NONBREAST CANCER; 2ND MALIGNANCIES; WOMEN; RADIOTHERAPY; DATABASE; SYSTEM; AGE;
D O I
10.1016/j.canep.2022.102311
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Breast cancer survivors may have increased risk of subsequent haematologic cancer. We compared their risk of haematologic cancers with the general population during 38 years of follow-up. Methods: Using population-based Danish medical registries, we assembled a nationwide cohort of women diagnosed with incident non-metastatic breast cancer during 1980-2017, with follow-up through 2018. We compared breast cancer survivors with the general population by computing standardised incidence ratios (SIR) and 95% confidence intervals (CI). Results: Among 101,117 breast cancer survivors, we observed 815 incident haematologic cancers (median follow-up: 7.9 years). We observed excess risk of acute myeloid leukaemia (AML) (SIR: 1.65, 95%CI: 1.33-2.01), particularly in women who received chemotherapy (SIR: 3.33, 95%CI: 2.24-4.75) and premenopausal women (SIR: 3.23, 95%CI: 2.41-4.25). The risk of acute lymphoid leukaemia (ALL) was increased (SIR: 2.25, 95%CI: 1.29-3.66), whereas the risk of chronic lymphoid leukaemia (CLL) was decreased (SIR: 0.66, 95%CI: 0.53-0.82). An additional analysis showed elevated risk of CLL 0-6 months after breast cancer diagnosis (SIR: 3.00 95%CI: 1.75-4.80). Conclusion: Compared to the general population, breast cancer survivors had elevated risk of AML, particularly when treated with chemotherapy. The risk of ALL was elevated, whereas the risk of CLL was lower. The higher risk of CLL in the first six months after diagnosis likely reflects surveillance bias-due to intensified diagnostic efforts at breast cancer diagnosis and treatment-prompting earlier detection. This has likely reduced the long-term risk of CLL in breast cancer survivors.
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页数:7
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