Comorbid autoimmune disorders in people with multiple sclerosis: A retrospective cohort study

被引：2

作者：

Rato, Miguel Leal ^{[1
,2
]}

Santos, Monica ^{[1
]}

de Sa, Joao ^{[1
,3
]}

Ferreira, Joao ^{[1
,3
]}

机构：

[1] Hosp Santa Maria, Ctr HospUniv Lisboa Norte, Dept Neurociencias & Saude Mental, Serv Neurol, Ave Prof Egas Moniz, P- 1649035 Lisbon, Portugal

[2] Univ Lisbon, Inst Farmacol & Neurociencias, Fac Med, Lisbon, Portugal

[3] Univ Lisbon, Ctr Estudos Egas Moniz, Fac Med, Lisbon, Portugal

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2023年 / 385卷

关键词：

Multiple sclerosis; Comorbidities; Autoimmunity; Immunophenotypes; DISEASE; PREVALENCE; FAMILIES; RISK;

D O I：

10.1016/j.jneuroim.2023.578226

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Most autoimmune disorders, including multiple sclerosis (MS), are influenced by shared genetic and environ-mental factors. We conducted a cohort study of people with MS to calculate the frequency of comorbid auto-immune disorders and characterize this cohort. Autoimmune diseases were present in 30 (8.6%) of 349 patients. The most prevalent diagnoses were autoimmune thyroiditis, type 1 diabetes mellitus, psoriasis, and inflamma-tory bowel disease. We found no association with demographic or clinical factors. In our cohort, autoimmune disorders were not uncommon. Identifying such comorbidities in people with MS can be determinant for un-derstanding disease mechanisms, treatment decisions and disease management.

引用

页数：4

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