Distribution of proteins for synaptic release in nerve endings associated with the trachealis muscle of rats

被引：1
|
作者：
Moriai, Hisae [1 ]
Yokoyama, Takuya [2 ]
Abdali, Sayed Sharif [1 ]
Nakamuta, Nobuaki [1 ]
Yamamoto, Yoshio [1 ,3 ]
机构：
[1] Iwate Univ, Fac Agr, Lab Vet Anat & Cell Biol, Morioka, Japan
[2] Iwate Med Univ, Dept Anat Cell Biol, Yahaba, Japan
[3] Iwate Univ, Fac Agr, Lab Vet Anat & Cell Biol, 18 8 Ueda 3 chome, Morioka, Iwate 0208550, Japan
来源：
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL | 2023年 / 244卷
关键词：
Trachealis muscle; Slowly adapting receptor; Glutamate; SNARE proteins; Immunohistochemistry; GLUTAMATE TRANSPORTER IMMUNOREACTIVITY; SENSORY RECEPTORS; MODULATION; TERMINALS; AIRWAYS; BODY; LUNG;
D O I：
10.1016/j.autneu.2022.103042
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The immunohistochemical localization of proteins for synaptic release was examined in smooth muscle -associated sensory nerve endings using whole-mount preparations of the rat trachea. Plant-like smooth muscle-associated nerve endings with immunoreactivity for Na+-K+-ATPase, alpha 3-subunit were identified in the trachealis muscle. VGLUT1, synapsin1, t-SNARE proteins (SNAP25 and syntaxin1), v-SNARE proteins (VAMP1 and VAMP2), and a presynaptic active zone-related protein (piccolo) were detected in the terminal parts of these endings. These results suggest that smooth muscle-associated nerve endings secrete glutamate to modulate sensorimotor functions in the lung deflation reflex.
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页数：5
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