Biocompatibility analysis of halloysite clay nanotubes

被引：13

作者：

Lazzara, Giuseppe ^{[1
]}

Bruno, Francesca ^{[2
]}

Brancato, Desiree ^{[2
]}

Sturiale, Valentina ^{[2
]}

D'Amico, Agata Grazia ^{[3
]}

Miloto, Stefana ^{[1
]}

Pasbakhsh, Pooria ^{[5
]}

D'Agata, Velia ^{[4
]}

Saccone, Salvatore ^{[2
]}

Federico, Concetta ^{[2
]}

机构：

[1] Univ Palermo, Dept Phys & Chem, Palermo, Italy

[2] Univ Catania, Dept Biol Geol & Environm Sci, Catania, Italy

[3] Univ Catania, Dept Drug & Hlth Sci, Catania, Italy

[4] Univ Catania Italy, Dept Biomed & Biotechnol Sci, Catania, Italy

[5] Monash Univ Malaysia, Dept Mech Engn, Selangor, Malaysia

来源：

MATERIALS LETTERS | 2023年 / 336卷

关键词：

Genotoxic assay; Cytotoxic assay; Nanotechnology; Halloysite; Nanotubes; OXIDE NANOPARTICLES;

D O I：

10.1016/j.matlet.2023.133852

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The biocompatibility of four different halloysite clay nanotubes (HNT-N,-U,-P,-S), from various deposits in the world, was evaluated. More precisely, we tested their cytogenetic effects through MTT assay (for cytotoxic ef-fects), and CBMN assay (for genotoxic effects) on mammalian cell cultures (CHO, HeLa, and HepG2 cell lines). Our results indicated a generally high level of biocompatibility of these new-generation products, however at high concentrations, and long times of exposition, we observed a moderate level of toxicity. Thus, we suggest caution in the future use of great amounts of HNTs due to their effects on living organisms.

引用

页数：4

共 50 条

[41] Automatic Echographic Detection of Halloysite Clay Nanotubes in a Low Concentration Range
Conversano, Francesco
Pisani, Paola
Casciaro, Ernesto
Di Paola, Marco
Leporatti, Stefano
Franchini, Roberto
Quarta, Alessandra
Gigli, Giuseppe
Casciaro, Sergio
NANOMATERIALS, 2016, 6 (04)
[42] In Vitro Cytotoxicity of Halloysite Clay Nanotubes Is Effectively Prevented by Surface Coating with PEG
Di Paola, Marco
Quarta, Alessandra
Di Corato, Riccardo
Conyersano, Francesco
Sbenaglia, Enzo A.
Gigli, Giuseppe
Casciaro, Sergio
Lay-Ekuakille, Aime
2016 NANOTECHNOLOGY FOR INSTRUMENTATION AND MEASUREMENT (NANOFIM), 2016,
[43] Luminescent copper(I, II) complex-anchored halloysite clay nanotubes
Mondragon, Margarita
Elizalde, Luis E.
Gomez-Vidales, Virginia
Arias, Eduardo
Moggio, Ivana
MATERIALS CHEMISTRY AND PHYSICS, 2018, 212 : 237 - 244
[44] Tuning the Wettability of Halloysite Clay Nanotubes by Surface Carbonization for Optimal Emulsion Stabilization
Owoseni, Olasehinde
Zhang, Yueheng
Su, Yang
He, Jibao
McPherson, Gary L.
Bose, Arijit
John, Vijay T.
LANGMUIR, 2015, 31 (51) : 13700 - 13707
[45] Improved biological performance of ketoprofen using novel modified halloysite clay nanotubes
Sid, Dounia
Baitiche, Milad
Arrar, Lekhmici
Djerboua, Ferhat
Bourzami, Riadh
Alcouffe, Pierre
Boutahala, Mokhtar
Gil, Antonio
David, Laurent
Le Borgne, Marc
APPLIED CLAY SCIENCE, 2022, 216
[46] Spectrophotometric and nucleic acid-binding properties of halloysite clay nanotubes and kaolinite
Malla, Shubha R. L.
Gujjari, Archana
Corona, Carlos E.
Beall, Gary W.
Lewis, L. Kevin
HELIYON, 2023, 9 (01)
[47] Covalently modified halloysite clay nanotubes: synthesis, properties, biological and medical applications
Massaro, M.
Lazzara, G.
Milioto, S.
Noto, R.
Riela, S.
JOURNAL OF MATERIALS CHEMISTRY B, 2017, 5 (16) : 2867 - 2882
[48] Preclinical developments of natural-occurring halloysite clay nanotubes in cancer therapeutics
Pereira, Irina
Saleh, Mahdi
Nunes, Claudia
Reis, Salette
Veiga, Francisco
Paiva-Santos, Ana Claudia
ADVANCES IN COLLOID AND INTERFACE SCIENCE, 2021, 291
[49] Conductive halloysite clay nanotubes for high performance sodium ion battery cathode
Cao, Xiang
Sun, Yingjuan
Sun, Yongrong
Xie, Dong
Li, Hongyan
Liu, Mingxian
APPLIED CLAY SCIENCE, 2021, 213
[50] Conductive halloysite clay nanotubes for high performance sodium ion battery cathode
Cao, Xiang
Sun, Yingjuan
Sun, Yongrong
Xie, Dong
Li, Hongyan
Liu, Mingxian
Applied Clay Science, 2021, 213

← 1 2 3 4 5 →