Biocompatibility analysis of halloysite clay nanotubes

被引：12

作者：

Lazzara, Giuseppe ^{[1
]}

Bruno, Francesca ^{[2
]}

Brancato, Desiree ^{[2
]}

Sturiale, Valentina ^{[2
]}

D'Amico, Agata Grazia ^{[3
]}

Miloto, Stefana ^{[1
]}

Pasbakhsh, Pooria ^{[5
]}

D'Agata, Velia ^{[4
]}

Saccone, Salvatore ^{[2
]}

Federico, Concetta ^{[2
]}

机构：

[1] Univ Palermo, Dept Phys & Chem, Palermo, Italy

[2] Univ Catania, Dept Biol Geol & Environm Sci, Catania, Italy

[3] Univ Catania, Dept Drug & Hlth Sci, Catania, Italy

[4] Univ Catania Italy, Dept Biomed & Biotechnol Sci, Catania, Italy

[5] Monash Univ Malaysia, Dept Mech Engn, Selangor, Malaysia

来源：

MATERIALS LETTERS | 2023年 / 336卷

关键词：

Genotoxic assay; Cytotoxic assay; Nanotechnology; Halloysite; Nanotubes; OXIDE NANOPARTICLES;

D O I：

10.1016/j.matlet.2023.133852

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The biocompatibility of four different halloysite clay nanotubes (HNT-N,-U,-P,-S), from various deposits in the world, was evaluated. More precisely, we tested their cytogenetic effects through MTT assay (for cytotoxic ef-fects), and CBMN assay (for genotoxic effects) on mammalian cell cultures (CHO, HeLa, and HepG2 cell lines). Our results indicated a generally high level of biocompatibility of these new-generation products, however at high concentrations, and long times of exposition, we observed a moderate level of toxicity. Thus, we suggest caution in the future use of great amounts of HNTs due to their effects on living organisms.

引用

页数：4

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