Antioxidant and Wound Healing Bioactive Potential of Extracts Obtained from Bark and Needles of Softwood Species

被引:7
|
作者
Geana, Elisabeta-Irina [1 ]
Ciucure, Corina Teodora [1 ]
Tamaian, Radu [1 ]
Marinas, Ioana Cristina [2 ]
Gaboreanu, Diana Madalina [2 ,3 ]
Stan, Miruna [2 ]
Chitescu, Carmen Lidia [4 ]
机构
[1] Natl Res & Dev Inst Cryogen & Isotop Technol, Ramnicu Valcea 240050, Romania
[2] Univ Bucharest ICUB, Dept Microbiol & Biochem, Res Inst, Bucharest 050567, Romania
[3] Natl Inst Res & Dev Biol Sci, Bucharest 060031, Romania
[4] Dunarea de Jos Univ Galati, Fac Med & Pharm, Galati 800008, Romania
关键词
antioxidant activity; antimicrobial activity; anti-hemolytic activity; coniferous biomass; phytochemical bioactive compounds; polyphenols; PI3K gamma; protein-ligand docking; SPRUCE PICEA-ABIES; ULTRASOUND-ASSISTED EXTRACTION; PROTEIN-LIGAND COMPLEXES; NF-KAPPA-B; PHENOLIC-COMPOUNDS; PINE BARK; BIOLOGICAL MACROMOLECULES; STAPHYLOCOCCUS-AUREUS; CONDENSED TANNINS; PDBBIND DATABASE;
D O I
10.3390/antiox12071383
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Interest in the extraction of phytochemical bioactive compounds, especially polyphenols from biomass, has recently increased due to their valuable biological potential as natural sources of antioxidants, which could be used in a wide range of applications, from foods and pharmaceuticals to green polymers and bio-based materials. The present research study aimed to provide a comprehensive chemical characterization of the phytochemical composition of forest biomass (bark and needles) of softwood species (Picea abies L., H. Karst., and Abies alba Mill.) and to investigate their in vitro antioxidant and antimicrobial activities to assess their potential in treating and healing infected chronic wounds. The DPPH radical-scavenging method and P-LD were used for a mechanistic explanation of the biomolecular effects of the investigated bioactive compounds. (+)-Catechin, epicatechin, rutin, myricetin, 4 hydroxybenzoic and p-cumaric acids, kaempherol, and apigenin were the main quantified polyphenols in coniferous biomass (in quantities around 100 mu g/g). Also, numerous phenolic acids, flavonoids, stilbenes, terpenes, lignans, secoiridoids, and indanes with antioxidant, antimicrobial, anti-inflammatory, antihemolytic, and anti-carcinogenic potential were identified. The Abies alba needle extract was more toxic to microbial strains than the eukaryotic cells that provide its active wound healing principles. In this context, developing industrial upscaling strategies is imperative for the long-term success of biorefineries and incorporating them as part of a circular bio-economy.
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页数:38
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