Rate of Endothelial Cell Loss and Graft Survival in Descemet Membrane Endothelial Keratoplasty in Eyes Requiring a Rebubble

被引:3
|
作者
Tapley, Jeffrey L. [1 ,4 ]
Hill, Jordan R. [2 ]
Bauer, Alex J. [3 ]
Straiko, Megan M. W. [3 ]
Straiko, Michael D. [2 ]
Terry, Mark A. [2 ]
机构
[1] Univ Alabama Birmingham, Cornea Serv, Birmingham, AL USA
[2] Devers Eye Inst, Cornea Serv, Portland, OR USA
[3] Lions VisionGift, Portland, OR USA
[4] Univ Alabama Birmingham, 1720 Univ Blvd,Suite 200, Birmingham, AL 35233 USA
关键词
Descemet membrane endothelial keratoplasty; endothelial cell loss; graft survival; rebubble; SULFUR-HEXAFLUORIDE SF6; AIR TAMPONADE; DMEK; DETACHMENT; TISSUE;
D O I
10.1097/ICO.0000000000003118
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose:We aimed to compare the rate of 6-month endothelial cell loss (ECL) and 6-month graft survival in eyes that did not require a postoperative rebubble with eyes that did require a postoperative rebubble after Descemet membrane endothelial keratoplasty (DMEK) surgery.Methods:A consecutive series of DMEK surgeries performed from September 2013 to March 2020 was retrospectively analyzed. Eyes that did not require a rebubble for graft detachment were compared with eyes with 1 rebubble and eyes with 2 or more rebubbles for 6-month ECL and graft survival. A subanalysis of the rebubble rate for different indications for transplantation was also performed.Results:One thousand two hundred ninety-eight eyes were included in this study. The 6-month ECL for eyes with no rebubbles, 1 rebubble, and & GE;2 rebubbles was 29.3% & PLUSMN; 16.2% (n = 793), 36.4% & PLUSMN; 18.6% (n = 97, P = 0.001), and 50.1% & PLUSMN; 19.6% (n = 28, P < 0.001), respectively. The 6-month graft survival rate for eyes with no rebubbles, 1 rebubble, and & GE;2 rebubbles was 99.5%, 97.8% (P = 0.035), and 81.8% (P < 0.001), respectively. When compared to the rebubble rate for DMEK for Fuchs dystrophy (156/1165 eyes = 13.4%), the rebubble rates were statistically higher for DMEK for failed penetrating keratoplasty (28.5%, P = 0.021) and pseudophakic bullous keratopathy (28.0%, P = 0.036).Conclusions:Eyes undergoing any rebubble procedure in the postoperative period after DMEK have an increased risk of endothelial cell loss and graft failure at 6 months postoperative. DMEK in eyes for failed penetrating keratoplasty and failed DMEK had the highest rebubble rate, with the former reaching statistical significance.
引用
收藏
页码:934 / 939
页数:6
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