Transplacental Transfer of SARS-CoV-2 Receptor-Binding Domain IgG Antibodies from Mothers to Neonates in a Cohort of Pakistani Unvaccinated Mothers

被引:1
|
作者
Harakeh, Steve [1 ,2 ]
Khan, Ihsan Alam [3 ,4 ]
Rani, Gulab Fatima [3 ]
Ibrahim, Muhammad [3 ]
Khan, Aysha Sarwar [3 ]
Almuhayawi, Mohammed [5 ]
Al-Raddadi, Rajaa [6 ]
Teklemariam, Addisu D. [7 ]
Hazzazi, Mohannad S. [8 ,9 ]
Bawazir, Waleed M. [8 ,9 ]
Niyazi, Hanouf A. [5 ]
Alamri, Turki [10 ]
Niyazi, Hatoon A. [5 ]
Yousafzai, Yasar Mehmood [3 ,11 ]
机构
[1] King Abdulaziz Univ, King Fahd Med Res Ctr, Jeddah 21589, Saudi Arabia
[2] King Abdulaziz Univ, Fac Med, Yousef Abdul Latif Jameel Sci Chair Prophet Med Ap, Jeddah 22230, Saudi Arabia
[3] Khyber Med Univ, Inst Pathol & Diagnost Med, Dept Hematol, Peshawar 25100, Pakistan
[4] Swat Med Coll, Dept Pathol, Swat 19200, Pakistan
[5] King Abdulaziz Univ, Fac Med, Dept Clin Microbiol & Immunol, Jeddah 21589, Saudi Arabia
[6] King Abdulaziz Univ, Fac Med, Community Med Dept, Jeddah 21589, Saudi Arabia
[7] King Abdulaziz Univ, Fac Sci, Dept Biol Sci, Jeddah 21589, Saudi Arabia
[8] King Abdulaziz Univ, Fac Appl Med Sci, Dept Med Lab Sci, Jeddah 22254, Saudi Arabia
[9] King Abdulaziz Univ, King Fahd Med Res Ctr, Hematol Res Unit, Jeddah 22254, Saudi Arabia
[10] King Abdulaziz Univ, Fac Med Rabigh, Family & Community Med Dept, Jeddah 21589, Saudi Arabia
[11] Rehman Med Inst, Hayatabad Phase 5, Peshawar 25600, Pakistan
关键词
transplacental passage; SARS-CoV-2; RBD IgG; transmission from mothers to neonates; Pakistani; COVID-19; CORONAVIRUS; INFECTION;
D O I
10.3390/biomedicines11061651
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The presence of COVID-19 antibodies in the maternal circulation is assumed to be protective for newborns against SARS-CoV-2 infection. We investigated whether maternal COVID-19 antibodies crossed the transplacental barrier and whether there was any difference in the hematological parameters of neonates born to mothers who recovered from COVID-19 during pregnancy. The cross-sectional study was conducted at the Saidu Group of Teaching Hospitals, located in Swat, Khyber Pakhtunkhwa. After obtaining written informed consent, 115 healthy, unvaccinated mother-neonate dyads were included. A clinical history of COVID-19-like illness, laboratory-confirmed diagnosis, and contact history were obtained. Serum samples from mothers and neonates were tested for SARS-CoV-2 anti-receptor-binding domain (anti-RBD) IgG antibodies. Hematological parameters were assessed with complete blood counts (CBC) and peripheral blood smear examinations. The study population consisted of 115 mothers, with a mean age of 29.44 & PLUSMN; 5.75 years, and most women (68/115 (59.1%)) were between 26 and 35 years of age. Of these mothers, 88/115 (76.5 percent) tested positive for SARS-CoV-2 anti-RBD IgG antibodies, as did 83/115 (72.2 percent) neonatal cord blood samples. The mean levels of SARS-CoV-2 IgG antibodies in maternal and neonatal blood were 19.86 & PLUSMN; 13.82 (IU/mL) and 16.16 & PLUSMN; 12.90 (IU/mL), respectively, indicating that maternal antibodies efficiently crossed the transplacental barrier with an antibody transfer ratio of 0.83. The study found no significant difference in complete blood count (CBC) parameters between seropositive and seronegative mothers, nor between neonates born to seropositive and seronegative mothers.
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页数:10
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