Total Synthesis, Revised Structure, and Biological Evaluation of Elgonene B and Analogues

被引：3

作者：

Mandal, Sudip ^{[1
]}

Mahananda, Dora ^{[1
]}

Dey, Sourav ^{[2
]}

Bharathavikru, Ruthrotha Selvi ^{[2
]}

Thirupathi, Barla ^{[1
]}

机构：

[1] Indian Inst Sci Educ & Res Berhampur, Dept Chem Sci, Transit Campus,Govt ITI Bldg, Berhampur 760010, Odisha, India

[2] Indian Inst Sci Educ & Res Berhampur, Dept Biol Sci, Transit Campus,Govt ITI Bldg, Berhampur 760010, Odisha, India

来源：

JOURNAL OF NATURAL PRODUCTS | 2023年 / 87卷 / 01期

关键词：

SELECTIVE SYNTHESIS; REAGENTS; CHLORIDE;

D O I：

10.1021/acs.jnatprod.3c00988

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Herein, we report the first total synthesis of elgonene B and its congeners, thus resulting in a revision of the configuration at the C-6 carbon of the originally proposed structure of elgonene B. This synthetic approach demonstrates the utility of several important reactions such as the chiral oxazaborolidinium ion-catalyzed Diels-Alder reaction, Ando's Horner-Wadsworth-Emmons olefination, and the intermolecular Nozaki-Hiyama-Kishi reaction as key steps. Additionally, the study explores the cytotoxic and antibacterial activities of elgonene B and its congeners (1-4).

引用

页码：152 / 159

页数：8

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