A framework for intestinal barrier dysfunction in aging

被引：6
|
作者：
Tatge, Lexus [1 ]
Fonseca, Rene Solano [1 ]
Douglas, Peter M. [1 ,2 ]
机构：
[1] Univ Texas Southwestern Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA
[2] Univ Texas Southwestern Med Ctr Dallas, Hamon Ctr Regenerat Sci & Med, Dallas, TX 75390 USA
来源：
NATURE AGING | 2023年 / 3卷 / 10期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/s43587-023-00492-0
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The intestinal epithelium serves as a barrier that facilitates interaction between intrinsic and environmental factors. Aging is accompanied by the gradual deterioration of this barrier. We postulate that barrier dysfunction results from defects in epithelial membrane trafficking that exacerbate age-related metabolic imbalances. Herein, we integrate barrier integrity, protein homeostasis, membrane trafficking and intracellular lipid sensing into an age-determining mechanism.
引用
收藏
页码：1172 / 1174
页数：3
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