Advances in the Treatment of Colorectal Cancer with Peritoneal Metastases focused on Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
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作者:
Jeon, Youngbae
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Gachon Univ, Coll Med, Gil Med Ctr, Dept Surg,Div Colon & Rectal Surg, Incheon, South KoreaGachon Univ, Coll Med, Gil Med Ctr, Dept Surg,Div Colon & Rectal Surg, Incheon, South Korea
Jeon, Youngbae
[1
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Park, Eun Jung
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Yonsei Univ, Gangnam Severance Hosp, Dept Surg, Div Colon & Rectal Surg,Coll Med, Seoul, South Korea
Yonsei Univ Coll Med, Gangnam Severance Hosp, Dept Surg, Div Colon & Rectal Surg, 20 Eonju Ro 63 Gil, Seoul 06229, South KoreaGachon Univ, Coll Med, Gil Med Ctr, Dept Surg,Div Colon & Rectal Surg, Incheon, South Korea
Park, Eun Jung
[2
,3
]
机构:
[1] Gachon Univ, Coll Med, Gil Med Ctr, Dept Surg,Div Colon & Rectal Surg, Incheon, South Korea
[2] Yonsei Univ, Gangnam Severance Hosp, Dept Surg, Div Colon & Rectal Surg,Coll Med, Seoul, South Korea
[3] Yonsei Univ Coll Med, Gangnam Severance Hosp, Dept Surg, Div Colon & Rectal Surg, 20 Eonju Ro 63 Gil, Seoul 06229, South Korea
In stage IV colorectal cancer (CRC), peritoneal metastasis is associated with poor prognosis. Hyperthermic intraperitoneal chemotherapy (HIPEC) after cytoreductive surgery (CRS) is an effective treatment option to obtain survival benefits in patients with peritoneal metastatic CRC. For several decades, numerous studies on CRS and HIPEC for peritoneal metastatic diseases have been conducted and are still in progress. The proper patient selection and preoperative assessment are crucial to achieve successful postoperative outcomes. Cytoreduction completeness and surgical techniques are required to improve oncologic outcomes after CRS plus HIPEC. The role of HIPEC for therapeutic and prophylactic aims are evaluated in recent clinical trials. In this article, we review the basic principles of CRS with HIPEC and recent clinical trials for the treatment of CRS plus HIPEC in CRC patients with PC.
机构:
Univ New S Wales, UNSW Dept Surg, St George Clin Sch, Sydney, NSW, Australia
Manly Hosp, Dept Gen Surg, Sydney, NSW, AustraliaUniv New S Wales, UNSW Dept Surg, St George Clin Sch, Sydney, NSW, Australia
Chua, Terence C.
Quinn, Liam E.
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Univ New S Wales, UNSW Dept Surg, St George Clin Sch, Sydney, NSW, AustraliaUniv New S Wales, UNSW Dept Surg, St George Clin Sch, Sydney, NSW, Australia
Quinn, Liam E.
Zhao, Jing
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Univ New S Wales, UNSW Dept Surg, St George Clin Sch, Sydney, NSW, AustraliaUniv New S Wales, UNSW Dept Surg, St George Clin Sch, Sydney, NSW, Australia
Zhao, Jing
Morris, David L.
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Univ New S Wales, UNSW Dept Surg, St George Clin Sch, Sydney, NSW, AustraliaUniv New S Wales, UNSW Dept Surg, St George Clin Sch, Sydney, NSW, Australia
机构:
Louisiana State Univ, Coll Sci, Sect Colon & Rectal Surg, New Orleans, LA 70112 USALouisiana State Univ, Coll Sci, Sect Colon & Rectal Surg, New Orleans, LA 70112 USA