Synthesis of Dendrimer Conjugates with Naproxen and their Anticancer Activity

被引：2

作者：

Castillo-Rodriguez, Irving Osiel ^{[1
]}

Ramirez-Apan, Teresa ^{[1
]}

Martinez-Garcia, Marcos ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Inst Quim, Circuito Exterior,Ciudad Univ, Coyoacan 04510, Mexico

来源：

CURRENT ORGANIC CHEMISTRY | 2023年 / 27卷 / 06期

关键词：

Dendrimers; anticancer activity; conjugates; naproxen; triethylene glycol; esterification reactions; PAMAM DENDRIMERS; DRUG; DELIVERY;

D O I：

10.2174/1385272827666230605160243

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Here we report the easy synthesis of dendrimer conjugates with four and eight naproxen moieties at the periphery. The synthesis involved two steps protection-deprotection sequence joined with triethylene glycol. A comparison was made between the cytotoxicity of dendron-naproxen conjugates and that of G1.0 G2.0 dendrimer-naproxen conjugates. Cytotoxicity studies showed that dendron conjugates were toxic towards all cancer cell lines studied, and their toxicity was significantly lower than that of dendrimer conjugates. However, dendrimer conjugates showed higher cytotoxicity and selectivity against K-562 and SKLU-1 than dendron conjugates.

引用

页码：540 / 545

页数：6

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