Characterization of a new polymeric food contact coating with emphasis on the chemical analysis and safety assessment of non-intentionally added substances (NIAS)

被引:2
|
作者
Mallen, Thomas R. [1 ]
Abston, Kadijah D. [1 ]
Parizek, Nathanial J. [1 ]
Negley, Judith [1 ]
Shores, Kevin S. [1 ]
Canatsey, Ryan D. [1 ]
Dubail, Sarah [2 ]
Maier, Mark S. [3 ]
Maffini, Maricel V.
机构
[1] Sherwin Williams Co, Packaging Div, Pittsburgh, PA 15233 USA
[2] Valspar France Res Corp SAS, 14 Rue Chanay, F-71700 Tournus, France
[3] Sheperian Toxicol LLC, Albuquerque, NM USA
关键词
Food; can coating; NIAS; Safety assessment; Polymer synthesis; Bioassay; BISPHENOL-A; MIGRATION; QUANTIFICATION; IDENTIFICATION; TOXICITY; EPOXY;
D O I
10.1016/j.fct.2023.113635
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Regulators have established safety requirements for food packaging raw materials and finished products, including by-products of polymer synthesis known as non-intentionally added substances (NIAS). However, there are no official guidance or regulations for best practices to evaluate the safety of NIAS. Here we described the process we followed to identify, characterize, and prioritize for safety assessment low molecular weight NIAS from an epoxy coating (V70) made with tetramethyl bisphenol F-based diglycidyl ether resin (TMBPF-DGE). We assembled a database of 15000 potential oligomers with masses up to 1000 Da and conducted extraction and migration testing of V70 coating. Acetonitrile extract contained higher number and concentration of substances compared to ethanolic-based food simulants. The extract contained 16 substances with matches in the database with estimated concentration of 18.27 mu g/6 dm2; seven of these substances have potentially genotoxic oxirane functionality. TMBPF-DGE + hydroquinone (TMBPF-DGE + HQ) was most abundant (55% of total concentra-tion) and was synthesized and prioritized for safety assessment. TMBPF-DGE + HQ exposure from can beverage was estimated at 5.2 mu g/person/day, and it was not mutagenic or genotoxic in in vitro assays. The overall mixture of substances that migrated into ethanolic simulant was also negative in the mutagenicity bioassay. Our findings suggest that exposure to TMBPF-DGE + HQ from the V70 coating is exceedingly small and that the coating migrates are not genotoxic.
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页数:8
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