Impact of IL-6-174G/C, IL-10-1082A/G Gene Polymorphisms on Toxoplasma gondii infections

Toxoplasma gondii is one of the most common intrauterine infections worldwide and the major cause of perinatal morbidity and mortality. This study aims to determine the genetic susceptibility of certain types of cytokine single nucleotide gene polymorphism to toxoplasmosis. Materials: the study involved 40 females with confirmed seropositive Toxoplasma gondii infection and 30 healthy females as the control group. Single nucleotide gene polymorphisms of IL-16-174G/C, IL-10-1082A/G, and TNF-alpha-308G/C were determined. IL-6-174G/C results showed no relation between GG and the disease, the protective effect of GC genotype, and CC as a risk factor with a 3-fold effect OR:3.22. C allele as a risk for the infection. For IL-10-1082A/G genotypes, the wild and mutant homozygotes were associated with the disease with almost 1.5 folded effects, OR: 1.46 and 1.56 respectively. While the mutant heterozygote has a protective effect against the disease, OR: 0.57. Conclusion: the study found a positive relation between the IL-6-174 CC genotype with 3 folded effects, and for IL-10-1082A/G the AA and AG were associated with the disease by 1.5 fold.