The LncRNA signature associated with cuproptosis as a novel biomarker of prognosis in immunotherapy and drug screening for clear cell renal cell carcinoma
被引:3
|
作者:
Zhang, Lishuo
论文数: 0引用数: 0
h-index: 0
机构:
Harbin Med Univ, Dept Urol, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R ChinaHarbin Med Univ, Dept Urol, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R China
Zhang, Lishuo
[1
]
Di, Longjiang
论文数: 0引用数: 0
h-index: 0
机构:
Southern Med Univ, Coll Basic Med, Guangzhou, Guangdong, Peoples R ChinaHarbin Med Univ, Dept Urol, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R China
Di, Longjiang
[2
]
Liu, Jinhui
论文数: 0引用数: 0
h-index: 0
机构:
Harbin Med Univ, Affiliated Hosp 2, Harbin, Heilongjiang, Peoples R ChinaHarbin Med Univ, Dept Urol, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R China
Liu, Jinhui
[3
]
Lei, Xianli
论文数: 0引用数: 0
h-index: 0
机构:
Harbin Med Univ, Harbin, Heilongjiang, Peoples R ChinaHarbin Med Univ, Dept Urol, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R China
Lei, Xianli
[4
]
Gu, Maoli
论文数: 0引用数: 0
h-index: 0
机构:
Harbin Med Univ, Dept Urol, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R ChinaHarbin Med Univ, Dept Urol, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R China
Gu, Maoli
[1
]
Zhang, Wenjing
论文数: 0引用数: 0
h-index: 0
机构:
Harbin Med Univ, Affiliated Hosp 2, Harbin, Heilongjiang, Peoples R ChinaHarbin Med Univ, Dept Urol, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R China
Zhang, Wenjing
[3
]
Wang, Yufu
论文数: 0引用数: 0
h-index: 0
机构:
Harbin Med Univ, Affiliated Hosp 2, Harbin, Heilongjiang, Peoples R ChinaHarbin Med Univ, Dept Urol, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R China
Wang, Yufu
[3
]
机构:
[1] Harbin Med Univ, Dept Urol, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R China
[2] Southern Med Univ, Coll Basic Med, Guangzhou, Guangdong, Peoples R China
[3] Harbin Med Univ, Affiliated Hosp 2, Harbin, Heilongjiang, Peoples R China
[4] Harbin Med Univ, Harbin, Heilongjiang, Peoples R China
Cuproptosis is a new form of cell death, the second form of metal ion-induced cell death defined after ferroptosis. Recently, cuproptosis has been suggested to be associated with tumorigenesis. However, the relationship between cuproptosis and patient prognosis in clear cell renal cell carcinoma (ccRCC) in the context of immunotherapy remains unknown. The aim of this study was to investigate the correlation between cuproptosis-related long non-coding RNA (lncRNA) and ccRCC in terms of immunity as well as prognosis. Clinical information on lncRNAs associated with differences in cuproptosis genes in ccRCC and normal tissues was collected from The Cancer Genome Atlas (TCGA) dataset. Univariate Cox regression was used to screen lncRNAs. A total of 11 lncRNAs closely associated with cuproptosis were further screened and established using the least absolute shrinkage and selection operator (LASSO) algorithm and multivariate Cox regression, and the samples were randomly divided into training and test groups. A risk prognostic model was constructed using the training group, and the model was validated using the test group. We investigated the predictive ability of the prognostic risk model in terms of clinical prognosis, tumor mutation, immune escape, immunotherapy, tumor microenvironment, immune infiltration levels, and tumor drug treatment of ccRCC. Using the median risk score, patients were divided into low and high-risk groups. Kaplan-Meier curves showed that the overall survival (OS) of patients in the high-risk group was significantly worse than low-risk group (p < 0.001). Receiver operating characteristic (ROC) curves further validated the reliability of our model. The model consistently and accurately predicted prognosis at 1, 3, and 5 years, with an AUC above 0.7. Tumor cell genes generally precede morphological abnormalities; therefore, the model we constructed can effectively compensate for the traditional method of evaluating the prognosis of patients with renal cancer, and our model was also clinically meaningful in predicting ccRCC staging. In addition, lower model risk scores determined by mutational load indicated a good chance of survival. The high-risk group had greater recruitment of immune cells, while the anti-immune checkpoint immunotherapy was less efficacious overall than that of the low-risk group. Tumor and immune-related pathways were enriched, and anti-tumor agents were selected to improve the survival of ccRCC. This prognostic risk model is based on the levels of cuproptosis-associated lncRNAs and provides a new perspective in the clinical assessment and precise treatment of ccRCC.
机构:
Chongqing Med Univ, Dept Bioinformat, Basic Med Sch, Chongqing 400016, Peoples R China
Chongqing Med Univ, Dept Biochem & Mol Biol, Basic Med Sch, Chongqing, Peoples R ChinaChongqing Med Univ, Dept Bioinformat, Basic Med Sch, Chongqing 400016, Peoples R China
Lai, Jiayi
Miao, Shiqi
论文数: 0引用数: 0
h-index: 0
机构:
Chongqing Med Univ, Dept Bioinformat, Basic Med Sch, Chongqing 400016, Peoples R China
Chongqing Med Univ, Dept Biochem & Mol Biol, Basic Med Sch, Chongqing, Peoples R ChinaChongqing Med Univ, Dept Bioinformat, Basic Med Sch, Chongqing 400016, Peoples R China
Miao, Shiqi
Ran, Longke
论文数: 0引用数: 0
h-index: 0
机构:
Chongqing Med Univ, Dept Bioinformat, Basic Med Sch, Chongqing 400016, Peoples R ChinaChongqing Med Univ, Dept Bioinformat, Basic Med Sch, Chongqing 400016, Peoples R China
机构:
Anhui Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 1, Hefei, Peoples R ChinaAnhui Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 1, Hefei, Peoples R China
Sun, Peng
Xu, Hua
论文数: 0引用数: 0
h-index: 0
机构:
Hefei Second Peoples Hosp, Dept Nursing, Hefei, Peoples R ChinaAnhui Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 1, Hefei, Peoples R China
Xu, Hua
Zhu, Ke
论文数: 0引用数: 0
h-index: 0
机构:
Anhui Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 1, Hefei, Peoples R ChinaAnhui Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 1, Hefei, Peoples R China
Zhu, Ke
Li, Min
论文数: 0引用数: 0
h-index: 0
机构:
Anhui Med Univ, Dept Oncol, Affiliated Hosp 1, Hefei, Peoples R ChinaAnhui Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 1, Hefei, Peoples R China
Li, Min
Han, Rui
论文数: 0引用数: 0
h-index: 0
机构:
Anhui Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 1, Hefei, Peoples R ChinaAnhui Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 1, Hefei, Peoples R China
Han, Rui
Shen, Jiran
论文数: 0引用数: 0
h-index: 0
机构:
Anhui Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 1, Hefei, Peoples R ChinaAnhui Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 1, Hefei, Peoples R China
Shen, Jiran
Xia, Xingyuan
论文数: 0引用数: 0
h-index: 0
机构:
Anhui Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 1, Hefei, Peoples R ChinaAnhui Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 1, Hefei, Peoples R China
Xia, Xingyuan
Chen, Xiaojuan
论文数: 0引用数: 0
h-index: 0
机构:
Hefei Second Peoples Hosp, Dept Infect Dis, Hefei, Peoples R ChinaAnhui Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 1, Hefei, Peoples R China
Chen, Xiaojuan
Fei, Guanghe
论文数: 0引用数: 0
h-index: 0
机构:
Anhui Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 1, Hefei, Peoples R ChinaAnhui Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 1, Hefei, Peoples R China
Fei, Guanghe
Zhou, Sijing
论文数: 0引用数: 0
h-index: 0
机构:
Anhui Med Univ, Dept Occupat Dis, Hefei Clin Coll 3, Hefei, Peoples R ChinaAnhui Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 1, Hefei, Peoples R China
Zhou, Sijing
Wang, Ran
论文数: 0引用数: 0
h-index: 0
机构:
Anhui Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 1, Hefei, Peoples R ChinaAnhui Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 1, Hefei, Peoples R China
机构:
Sun Yat sen Univ, Affiliated Hosp 1, Organ Transplant Ctr, Guangzhou, Peoples R China
Sun Yat sen Univ, Affiliated Hosp 1, Guangdong Prov Key Lab Organ Donat & Transplant Im, Guangzhou, Peoples R China
Sun Yat sen Univ, Affiliated Hosp 1, Guangdong Prov Int Cooperat Base Sci & Technol Org, Guangzhou, Peoples R ChinaSun Yat sen Univ, Affiliated Hosp 1, Organ Transplant Ctr, Guangzhou, Peoples R China
Peng, Linjie
Liang, Jiaming
论文数: 0引用数: 0
h-index: 0
机构:
Guangzhou Med Univ, Dept Internal Med, Affiliated Hosp 2, Guangzhou, Peoples R ChinaSun Yat sen Univ, Affiliated Hosp 1, Organ Transplant Ctr, Guangzhou, Peoples R China
Liang, Jiaming
Wang, Qi
论文数: 0引用数: 0
h-index: 0
机构:
Guangzhou Med Univ, Natl Clin Res Ctr Resp Dis, State Key Lab Resp Dis, Affiliated Hosp 1, Guangzhou, Peoples R ChinaSun Yat sen Univ, Affiliated Hosp 1, Organ Transplant Ctr, Guangzhou, Peoples R China
Wang, Qi
Chen, Guodong
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat sen Univ, Affiliated Hosp 1, Organ Transplant Ctr, Guangzhou, Peoples R China
Sun Yat sen Univ, Affiliated Hosp 1, Guangdong Prov Key Lab Organ Donat & Transplant Im, Guangzhou, Peoples R China
Sun Yat sen Univ, Affiliated Hosp 1, Guangdong Prov Int Cooperat Base Sci & Technol Org, Guangzhou, Peoples R ChinaSun Yat sen Univ, Affiliated Hosp 1, Organ Transplant Ctr, Guangzhou, Peoples R China
机构:Shanxi Medical University School and Hospital of Stomatology,Department of Oral Medicine, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials
Shuang Liang
Lanting Ji
论文数: 0引用数: 0
h-index: 0
机构:Shanxi Medical University School and Hospital of Stomatology,Department of Oral Medicine, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials
Lanting Ji
Zhenyuan Yu
论文数: 0引用数: 0
h-index: 0
机构:Shanxi Medical University School and Hospital of Stomatology,Department of Oral Medicine, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials
Zhenyuan Yu
YaHsin Cheng
论文数: 0引用数: 0
h-index: 0
机构:Shanxi Medical University School and Hospital of Stomatology,Department of Oral Medicine, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials
YaHsin Cheng
Ruifang Gao
论文数: 0引用数: 0
h-index: 0
机构:Shanxi Medical University School and Hospital of Stomatology,Department of Oral Medicine, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials
Ruifang Gao
Wenpeng Yan
论文数: 0引用数: 0
h-index: 0
机构:Shanxi Medical University School and Hospital of Stomatology,Department of Oral Medicine, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials
Wenpeng Yan
Fang Zhang
论文数: 0引用数: 0
h-index: 0
机构:Shanxi Medical University School and Hospital of Stomatology,Department of Oral Medicine, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials
机构:
Fujian Normal Univ, Biomed Res Ctr South China, Fujian Key Lab Innate Immune Biol, Qishan Campus, Fuzhou, Peoples R ChinaFujian Normal Univ, Biomed Res Ctr South China, Fujian Key Lab Innate Immune Biol, Qishan Campus, Fuzhou, Peoples R China
Zhao, Guangjian
Zheng, Jianpei
论文数: 0引用数: 0
h-index: 0
机构:
Fujian Normal Univ, Biomed Res Ctr South China, Fujian Key Lab Innate Immune Biol, Qishan Campus, Fuzhou, Peoples R ChinaFujian Normal Univ, Biomed Res Ctr South China, Fujian Key Lab Innate Immune Biol, Qishan Campus, Fuzhou, Peoples R China
Zheng, Jianpei
Tang, Kai
论文数: 0引用数: 0
h-index: 0
机构:
Fujian Normal Univ, Biomed Res Ctr South China, Fujian Key Lab Innate Immune Biol, Qishan Campus, Fuzhou, Peoples R ChinaFujian Normal Univ, Biomed Res Ctr South China, Fujian Key Lab Innate Immune Biol, Qishan Campus, Fuzhou, Peoples R China
Tang, Kai
Chen, Qi
论文数: 0引用数: 0
h-index: 0
机构:
Fujian Normal Univ, Biomed Res Ctr South China, Fujian Key Lab Innate Immune Biol, Qishan Campus, Fuzhou, Peoples R ChinaFujian Normal Univ, Biomed Res Ctr South China, Fujian Key Lab Innate Immune Biol, Qishan Campus, Fuzhou, Peoples R China