Bioinspired Plasmo-virus for Point-of-Care SARS-CoV-2 Detection

被引：12
|
作者：
Park, Younggeun [1 ,2 ]
Ryu, Byunghoon [1 ,4 ]
Ki, Seung Jun [1 ]
Chen, Mingze [1 ]
Liang, Xiaogan [1 ,2 ]
Kurabayashi, Katsuo [3 ]
机构：
[1] Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Weil Inst Crit Care Res & Innovat, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Dept Elect Engn & Comp Sci, Ann Arbor, MI 48109 USA
[4] Inha Univ, Dept Mech Engn, Incheon 22212, South Korea
来源：
NANO LETTERS | 2023年 / 23卷 / 01期
基金：
美国国家科学基金会;
关键词：
Airborne viral particle; severe acute respiratory syndrome coronavirus 2; plasmonic nanogap; point-of-care biosensor; NANOSCALE OPTICAL BIOSENSOR; RANGE DISTANCE DEPENDENCE; RESONANCE; NANOPARTICLES;
D O I：
10.1021/acs.nanolett.2c03700
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Directly identifying the presence of the virus in infected hosts with an appropriate speed and sensitivity permits early epidemic management even during the presymptomatic incubation period of infection. Here, we synthesize a bioinspired plasmo-virus (BPV) particle for rapid and sensitive point-of-care (POC) detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) via a self assembled plasmonic nanoprobe array on spike proteins. The BPV enables strong near-infrared (NIR) extinction peaks caused by plasmonic nanogaps. We quantify SARS-CoV-2 in viral transport medium (VTM) at low titers within 10 min with a limit of detection (LOD) of 1.4 x 101 pfu/mL, which is 103 times more sensitive than the current gold-standard method. The high-sensitivity and high-speed POC detection may be widely used for the timely, individualized diagnosis of infectious agents in low-resource settings.
引用
收藏
页码：98 / 106
页数：9
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