The role of receptor-type protein tyrosine phosphatases in cancer

被引：3

作者：

Lv, Zhengyuan ^{[1
]}

Wang, Tianming ^{[1
,2
]}

Cao, Xin ^{[1
]}

Sun, Mengting ^{[3
]}

Qu, Yuan ^{[4
]}

机构：

[1] Nanjing Med Univ, Sch Basic Med Sci, Dept Med Genet, Nanjing, Peoples R China

[2] Nanjing Med Univ, Translat Med Res Ctr, Cent Lab, Affiliated Jiangning Hosp, Nanjing, Peoples R China

[3] Nanjing Med Univ, Biobank Jiangsu Inst Canc Res, Affiliated Canc Hosp, Nanjing, Peoples R China

[4] Nanjing Med Univ, Jiangsu Canc Hosp, Jiangsu Inst Canc Res, Affiliated Canc Hosp, Nanjing, Peoples R China

来源：

PRECISION MEDICAL SCIENCES | 2023年 / 12卷 / 01期

关键词：

cancer; RPTPs; reversible phosphorylation; GROWTH-FACTOR RECEPTOR; HEPATOCELLULAR-CARCINOMA; TUMOR-SUPPRESSOR; BETA-CATENIN; STAT3; ACTIVATION; OXIDATIVE STRESS; GASTRIC-CANCER; CELL-DEATH; CD45; PROMOTES;

D O I：

10.1002/prm2.12090

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Receptor-type protein tyrosine phosphatases (RPTPs), Class I protein tyrosine phosphatases, are involved in human tumor cell proliferation, apoptosis, migration, and invasion through reversible phosphorylation of tyrosine residues. This review summarizes the expression and role of RPTPs in cancer and illustrates the signaling pathway mechanisms of effecting oncogenesis, tumor progression, prognosis, and angiogenesis, so as to provide more effective targets for gene therapy of related cancers.

引用

页码：57 / 66

页数：10

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