Engineered elastin-like polypeptides: An efficient platform for enhanced cancer treatment

被引：4
|
作者：
Jiang, Aiguo [1 ]
Guan, Xinqiang [2 ]
He, Lianping [3 ]
Guan, Xingang [1 ,3 ]
机构：
[1] Taizhou Univ, Affiliated Wenling Hosp, Dept Resp Med, Taizhou, Peoples R China
[2] Lanzhou Univ, Hosp 2, Dept Cardiac Surg, Lanzhou, Peoples R China
[3] Taizhou Univ, Sch Med, Dept Basic Med, Taizhou, Peoples R China
来源：
FRONTIERS IN PHARMACOLOGY | 2023年 / 13卷
关键词：
elastin-like polypeptide; drug delivery; nanoparticle; inverse transition cycling; cancer therapy; INHIBIT TUMOR-GROWTH; DRUG; NANOPARTICLES; PEPTIDE; COMBINATION; EFFICACY; DELIVERY; POLYMER; DESIGN;
D O I：
10.3389/fphar.2022.1113079
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Drug delivery systems (DDSs) have recently gained widespread attention for improving drug loading and delivery efficiency in treating many cancers. Elastin-like polypeptides (ELPs) are synthetic peptides derived from a precursor of elastin (tropoelastin), reserving similar structural and physicochemical properties. ELPs have gained a variety of applications in tissue engineering and cancer therapy due to their excellent biocompatibility, complete degradability, temperature-responsive property, controllable sequence and length, and precisely tuned structure and function. ELPs-based drug delivery systems can improve the pharmacokinetics and biodistribution of therapeutic reagents, leading to enhanced antitumor efficacy. In this review, we summarize the recent application of ELPs in cancer treatment, focusing on the delivery of functional peptides, therapeutic proteins, small molecule drugs, and photosensitizers.
引用
收藏
页数：6
相关论文
共 50 条
  • [21] Genetically Encoded Elastin-Like Polypeptides for Drug Delivery
    Jenkins, Irene C.
    Milligan, Joshua J.
    Chilkoti, Ashutosh
    ADVANCED HEALTHCARE MATERIALS, 2021, 10 (13)
  • [22] Cononsolvency of Elastin-like Polypeptides in Water/Alcohol Solutions
    Mills, Carolyn E.
    Ding, Erika
    Olsen, Bradley D.
    BIOMACROMOLECULES, 2019, 20 (06) : 2167 - 2173
  • [23] Interactions of elastin-like polypeptides with model membranes on GUVs
    Weinberger, A.
    Macewan, S.
    Schmatko, T.
    Schroder, A.
    Chilkoti, A.
    Marques, C. M.
    EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2013, 42 : S158 - S158
  • [24] Post-modifications of recombinant elastin-like polypeptides
    Garanger, Elisabeth
    Petitdemange, Rosine
    Garbay, Bertrand
    Deming, Timothy
    Lecommandoux, Sebastien
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 252
  • [25] Elastin-like polypeptides as thermally targeted drug carriers
    Meyer, Dan
    Chilkoti, Ashutosh
    Annals of Biomedical Engineering, 2000, 28 (SUPPL. 1)
  • [26] Drug delivery to solid tumors by elastin-like polypeptides
    McDaniel, Jonathan R.
    Callahan, Daniel J.
    Chilkoti, Ashutosh
    ADVANCED DRUG DELIVERY REVIEWS, 2010, 62 (15) : 1456 - 1467
  • [27] Generation of a Monoclonal Antibody to Detect Elastin-like Polypeptides
    Kouhi, Aida
    Yao, Zhiyuan
    Zheng, Long
    Li, Zhe
    Hu, Peisheng
    Epstein, Alan L.
    MacKay, J. Andrew
    BIOMACROMOLECULES, 2019, 20 (08) : 2942 - 2952
  • [28] Elastin-Like Polypeptides: Biomedical Applications of Tunable Biopolymers
    MacEwan, Sarah R.
    Chilkoti, Ashutosh
    BIOPOLYMERS, 2010, 94 (01) : 60 - 77
  • [29] Elastin-like polypeptides as models of intrinsically disordered proteins
    Roberts, Stefan
    Dzuricky, Michael
    Chilkoti, Ashutosh
    FEBS LETTERS, 2015, 589 (19) : 2477 - 2486
  • [30] Emerging Role of Elastin-Like Polypeptides in Regenerative Medicine
    Sarangthem, Vijaya
    Singh, Thoudam Debraj
    Dinda, Amit Kumar
    ADVANCES IN WOUND CARE, 2021, 10 (05) : 257 - 269
12345