Palladium-Catalyzed Carbonylative Synthesis of Polycyclic 3,4-Dihydroquinolin-2(1H)-one Scaffolds Containing Perfluoroalkyl and Carbonyl Units

被引：16

作者：

Wang, Shangyuan ^{[1
]}

Zhao, Jiajun ^{[1
]}

Ying, Jun ^{[1
]}

Wu, Xiao-Feng ^{[2
,3
]}

机构：

[1] Zhejiang Sci Tech Univ, Sch Chem & Chem Engn, Key Lab Surface & Interface Sci Polymer Mat Zhejia, Hangzhou 310018, Peoples R China

[2] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian Natl Lab Clean Energy, Dalian 116023, Liaoning, Peoples R China

[3] Leibniz Inst Katalyse eV, Albert Einstein Str 29a, D-18059 Rostock, Germany

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 28期

关键词：

CYCLIZATION; ALKYNES;

D O I：

10.1021/acs.orglett.3c01879

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A palladium-catalyzed one-pot two-step radical mediatedcarbonylativecyclization of 1,7-enynes with perfluoroalkyl iodides and Mo-(CO)(6) has been developed for the construction of polycyclic 3,4-dihydroquinolin-2-(1H)-one scaffolds. This method realizes a facile synthesisof various polycyclic 3,4-dihydroquinolin-2-(1H)-onederivatives containing perfluoroalkyl and carbonyl units in high yields.Moreover, modifications of several bioactive molecules were demonstrated using this protocol.

引用

页码：5314 / 5318

页数：5

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