Palladium-Catalyzed Carbonylative Synthesis of Polycyclic 3,4-Dihydroquinolin-2(1H)-one Scaffolds Containing Perfluoroalkyl and Carbonyl Units

被引：16
|
作者：
Wang, Shangyuan [1 ]
Zhao, Jiajun [1 ]
Ying, Jun [1 ]
Wu, Xiao-Feng [2 ,3 ]
机构：
[1] Zhejiang Sci Tech Univ, Sch Chem & Chem Engn, Key Lab Surface & Interface Sci Polymer Mat Zhejia, Hangzhou 310018, Peoples R China
[2] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian Natl Lab Clean Energy, Dalian 116023, Liaoning, Peoples R China
[3] Leibniz Inst Katalyse eV, Albert Einstein Str 29a, D-18059 Rostock, Germany
来源：
ORGANIC LETTERS | 2023年 / 25卷 / 28期
关键词：
CYCLIZATION; ALKYNES;
D O I：
10.1021/acs.orglett.3c01879
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A palladium-catalyzed one-pot two-step radical mediatedcarbonylativecyclization of 1,7-enynes with perfluoroalkyl iodides and Mo-(CO)(6) has been developed for the construction of polycyclic 3,4-dihydroquinolin-2-(1H)-one scaffolds. This method realizes a facile synthesisof various polycyclic 3,4-dihydroquinolin-2-(1H)-onederivatives containing perfluoroalkyl and carbonyl units in high yields.Moreover, modifications of several bioactive molecules were demonstrated using this protocol.
引用
收藏
页码：5314 / 5318
页数：5
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