MOTS-c Functionally Prevents Metabolic Disorders

被引:8
|
作者
Gao, Yue [1 ,2 ,3 ]
Wei, Xinran [1 ,2 ,3 ]
Wei, Pingying [1 ]
Lu, Huijie [1 ]
Zhong, Luying [1 ]
Tan, Jie [3 ]
Liu, Hongbo [2 ,4 ]
Liu, Zheng [1 ,2 ]
机构
[1] Guilin Med Univ, Coll Med Lab Sci, Guilin 541004, Peoples R China
[2] Guilin Med Univ, Affiliated Hosp 2, Dept Lab Med, Guilin 541199, Peoples R China
[3] Guilin Med Univ, Guangxi Key Lab Brain & Cognit Neurosci, Guilin 541199, Peoples R China
[4] Guangxi Hlth Commiss, Key Lab Glucose & Lipid Metab Disorders, Guilin 541199, Peoples R China
基金
中国国家自然科学基金;
关键词
MOTS-c; insulin resistance; obesity; muscle function; bone metabolism; immune regulation; aging; MITOCHONDRIAL-DERIVED PEPTIDE; PROTEIN; OBESITY; DELIVERY; MICE;
D O I
10.3390/metabo13010125
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Mitochondrial-derived peptides are a family of peptides encoded by short open reading frames in the mitochondrial genome, which have regulatory effects on mitochondrial functions, gene expression, and metabolic homeostasis of the body. As a new member of the mitochondrial-derived peptide family, mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) is regarding a peptide hormone that could reduce insulin resistance, prevent obesity, improve muscle function, promote bone metabolism, enhance immune regulation, and postpone aging. MOTS-c plays these physiological functions mainly through activating the AICAR-AMPK signaling pathways by disrupting the folate-methionine cycle in cells. Recent studies have shown that the above hormonal effect can be achieved through MOTS-c regulating the expression of genes such as GLUT4, STAT3, and IL-10. However, there is a lack of articles summarizing the genes and pathways involved in the physiological activity of MOTS-c. This article aims to summarize and interpret the interesting and updated findings of MOTS-c-associated genes and pathways involved in pathological metabolic processes. Finally, it is expected to develop novel diagnostic markers and treatment approaches with MOTS-c to prevent and treat metabolic disorders in the future.
引用
收藏
页数:14
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