Risk of Fracture and Osteoporosis in Patients With COPD and Inhaled Corticosteroids Treatment

被引：4
|
作者：
Zhang, Nini [1 ]
Fan, Xinhui [1 ]
Zhang, Yuyu [2 ]
Xu, Ning [3 ]
Li, Li [4 ]
机构：
[1] Yanan Univ, Sch Med, Yanan 716000, Shaanxi, Peoples R China
[2] Fourth Mil Med Univ, Xijing Hosp, Dept Gen Practice, Xian 710032, Shaanxi, Peoples R China
[3] First Hosp Yulin, Dept Crit Care Med, Yulin 719000, Shaanxi, Peoples R China
[4] First Hosp Yulin, Dept Resp Med, Yulin 719000, Shaanxi, Peoples R China
来源：
RESPIRATORY CARE | 2023年 / 68卷 / 12期
关键词：
COPD; inhaled corticosteroids; fracture; osteoporosis; randomized controlled trials; meta-analysis; OBSTRUCTIVE PULMONARY-DISEASE; FLUTICASONE PROPIONATE/SALMETEROL 250/50; 100/25; MU-G; LUNG-FUNCTION; RANDOMIZED-TRIAL; DOUBLE-BLIND; PROPIONATE; SALMETEROL; FUROATE/VILANTEROL; EXACERBATIONS;
D O I：
10.4187/respcare.10933
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
BACKGROUND: There are disputes whether inhaled corticosteroids (ICS) increase the incidence of fracture or osteoporosis among patients with COPD. The aim of this meta-analysis was to assess the effect of ICS treatment on the risk of fracture and osteoporosis in subjects with COPD. METHODS: This study included parallel-group randomized controlled trials (RCTs) comparing ICS and control (non-ICS) therapy for subjects with COPD that reported adverse events including fractures or osteoporosis. Studies were found using MEDLINE/PubMed, Embase, and Cochrane Library databases between 1998-September 2022. Pooled risk ratios (RRs) and 95% CIs were calculated for primary outcomes. RESULTS: A total of 61,380 participants from 26 RCTs were included in the meta-analysis. Exposure to ICS did not increase the risk of fracture (RR 1.10 [95% CI 0.98-1.23], P =.10) or osteoporosis risk (RR 0.93 [95% CI 0.49-1.79], P 5.84) in subjects with COPD. CONCLUSIONS: ICS use did not increase the incidence of fracture or osteoporosis in subjects with COPD.
引用
收藏
页码：1719 / 1727
页数：9
相关论文
共 50 条
  • [41] Inhaled corticosteroids and the risk of type 2 diabetes among Swedish COPD patients
    Stallberg, Bjorn
    Janson, Christer
    Lisspers, Karin
    Johansson, Gunnar
    Gutzwiller, Florian S.
    Mezzi, Karen
    Bjerregaard, Bine Kjoeller
    Kejs, Anne Mette Tranberg
    Jorgensen, Leif
    Larsson, Kjell
    NPJ PRIMARY CARE RESPIRATORY MEDICINE, 2020, 30 (01)
  • [42] Managing the safety of inhaled corticosteroids in COPD and the risk of pneumonia
    Liapikou, Adamantia
    Toumbis, Michael
    Torres, Antoni
    EXPERT OPINION ON DRUG SAFETY, 2015, 14 (08) : 1237 - 1247
  • [43] Discontinuation of Inhaled Corticosteroids in COPD and the Risk Reduction of Pneumonia
    Suissa, Samy
    Coulombe, Janie
    Ernst, Pierre
    CHEST, 2015, 148 (05) : 1177 - 1183
  • [44] Risk of Pneumonia with Different Inhaled Corticosteroids in COPD Patients: A Meta-Analysis
    Zhang, Qian
    Li, Shuo
    Zhou, Wei
    Yang, Xia
    Li, Jinna
    Cao, Jie
    COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 2020, 17 (04) : 462 - 469
  • [45] Inhaled corticosteroids and the risk of type 2 diabetes among Swedish COPD patients
    Björn Ställberg
    Christer Janson
    Karin Lisspers
    Gunnar Johansson
    Florian S. Gutzwiller
    Karen Mezzi
    Bine Kjoeller Bjerregaard
    Anne Mette Tranberg Kejs
    Leif Jorgensen
    Kjell Larsson
    npj Primary Care Respiratory Medicine, 30
  • [46] Are COPD patients with pneumonia who are taking inhaled corticosteroids at higher risk of dying?
    Restrepo, M. I.
    Mortensen, E. M.
    Anzueto, A.
    EUROPEAN RESPIRATORY JOURNAL, 2011, 38 (01) : 1 - 3
  • [47] A systematic review of blood eosinophils and continued treatment with inhaled corticosteroids in patients with COPD
    Dalin, Dagmar Abelone
    Lokke, Anders
    Kristiansen, Pernille
    Jensen, Charlotte
    Birkefoss, Kirsten
    Christensen, Hanne Rolighed
    Godtfredsen, Nina Skavlan
    Hilberg, Ole
    Rohde, Jeanett Friis
    Ussing, Anja
    Vermehren, Charlotte
    Handel, Mina Nicole
    RESPIRATORY MEDICINE, 2022, 198
  • [48] Inhaled corticosteroids: a controversial add-on treatment in COPD
    Puhan, M. A.
    EUROPEAN RESPIRATORY JOURNAL, 2010, 36 (04) : 973 - 974
  • [49] Corticosteroids for asthma increase risk of osteoporosis and fracture
    Reactions Weekly, 2020, 1828 (1) : 6 - 6
  • [50] Pneumonia risk in COPD patients on long term inhaled corticosteroids - Data from the European COPD audit<%
    Saleh, Aarash
    Lopez-Campos, Jose
    Hartl, Sylvia
    Pozo-Rodriguez, Francisco
    Roberts, Michael
    EUROPEAN RESPIRATORY JOURNAL, 2013, 42
12345