Isochromenes from the Nicotiana tabacum-Derived Endophytic Fungus Aspergillus versicolor and Their Bioactivities

被引：1
|
作者：
Liu, Hua-Yin [1 ,2 ,3 ]
Yang, Feng-Xian [1 ,4 ,5 ]
Dai, Jia-Meng [1 ,4 ,5 ]
Liang, Meng-Jie [1 ,2 ,3 ]
Xiong, Wen [1 ]
Mi, Qi-Li [4 ,5 ]
Li, Xue-Mei [4 ,5 ]
Wang, Kai [4 ,5 ]
Deng, Liang [2 ,3 ]
Hu, Qiufen [4 ,5 ]
Zhang, Jian-Duo [1 ]
机构：
[1] China Tobacco Yunnan Ind Co Ltd, Yunnan Key Lab Tobacco Chem, Kunming 650231, Peoples R China
[2] Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Peoples R China
[3] Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Peoples R China
[4] Yunnan Minzu Univ, Key Lab Chem Ethn Med Resources, State Ethn Affairs Commiss, Kunming 650031, Peoples R China
[5] Yunnan Minzu Univ, Minist Educ, Kunming 650031, Peoples R China
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2023年 / 59卷 / 01期
基金：
中国国家自然科学基金;
关键词：
isochromene; endophytic fungus Aspergillus versicolor; anti-TMV; anti-MRSA; FERMENTATION PRODUCTS; DERIVATIVES; ANTIBACTERIAL; BUTYROLACTONES; ISOCOUMARIN;
D O I：
10.1007/s10600-023-03913-z
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two new isochromenes, 5-methoxy-3-methyl-7-prenyl-1H-isochromene (1) and 7-(3-hydroxypropyl)-5-methoxy-3-methyl-1H-isochromene (2), along with four known ones (3-6) were isolated from the fermentation products of the Nicotiana tabacum-derived endophytic fungus Aspergillus versicolor. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were evaluated for their anti-tobacco mosaic virus (anti-TMV) and anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activities. The results showed that compounds 1 and 2 exhibited potential anti-TMV activities with inhibition rates of 36.5 and 42.2%, respectively, and also showed good anti-MRSA activities with IZD of 16.8 +/- 2.2 and 20.6 +/- 2.5 mm, respectively.
引用
收藏
页码：41 / 45
页数：5
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