PET/MR imaging of inflammation in atherosclerosis

被引：21

作者：

Senders, Max L. L. ^{[1
,2
]}

Calcagno, Claudia ^{[1
]}

Tawakol, Ahmed ^{[3
,4
]}

Nahrendorf, Matthias ^{[5
,6
]}

Mulder, Willem J. M. ^{[2
,7
,8
,9
]}

Fayad, Zahi A. A. ^{[1
]}

机构：

[1] Icahn Sch Med Mt Sinai, Biomed Engn & Imaging Inst, New York, NY 10029 USA

[2] Univ Amsterdam, Amsterdam Univ Med Ctr, Dept Biomed Engn & Phys, Amsterdam, Netherlands

[3] Harvard Med Sch, Massachusetts Gen Hosp, Cardiol Div, Boston, MA USA

[4] Harvard Med Sch, Massachusetts Gen Hosp, Cardiovasc Imaging Res Ctr, Boston, MA USA

[5] Harvard Med Sch, Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA USA

[6] Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Boston, MA USA

[7] Radboud Univ Nijmegen, Med Ctr, Radboud Inst Mol Life Sci RIMLS, Dept Internal Med, Nijmegen, Netherlands

[8] Radboud Univ Nijmegen, Med Ctr, Radboud Ctr Infect Dis RCI, Nijmegen, Netherlands

[9] Eindhoven Univ Technol, Dept Biochem Engn, Lab Chem Biol, Eindhoven, Netherlands

来源：

NATURE BIOMEDICAL ENGINEERING | 2023年 / 7卷 / 03期

基金：

美国国家卫生研究院;

关键词：

ACUTE MYOCARDIAL-INFARCTION; CONTRAST-ENHANCED MRI; C-REACTIVE PROTEIN; IN-VIVO; VASCULAR INFLAMMATION; CAROTID PLAQUE; SUBCLINICAL ATHEROSCLEROSIS; CLONAL HEMATOPOIESIS; METABOLIC-ACTIVITY; LESION DEVELOPMENT;

D O I：

10.1038/s41551-022-00970-7

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Myocardial infarction, stroke, mental disorders, neurodegenerative processes, autoimmune diseases, cancer and the human immunodeficiency virus impact the haematopoietic system, which through immunity and inflammation may aggravate pre-existing atherosclerosis. The interplay between the haematopoietic system and its modulation of atherosclerosis has been studied by imaging the cardiovascular system and the activation of haematopoietic organs via scanners integrating positron emission tomography and resonance imaging (PET/MRI). In this Perspective, we review the applicability of integrated whole-body PET/MRI for the study of immune-mediated phenomena associated with haematopoietic activity and cardiovascular disease, and discuss the translational opportunities and challenges of the technology.

引用

页码：202 / 220

页数：19

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