How Supplementation with SOD-Rich Plant Extract, Combined with Gliadin, Can Affect Oxidative Stress Markers and Zonulin Levels in Exercise-Induced Oxidative Stress

被引:1
|
作者
Dudasova Petrovicova, Olina [1 ]
Stankovic, Ivan [1 ]
Dordevic, Brizita [1 ]
Dopsaj, Violeta [1 ]
Milinkovic, Neda [1 ]
Dopsaj, Milivoj [2 ]
机构
[1] Univ Belgrade, Fac Pharm, Vojvode Stepe 450, Belgrade 11221, Serbia
[2] Univ Belgrade, Fac Sport & Phys Educ, Blagoja Parovica 156, Belgrade 11000, Serbia
关键词
oxidative stress; athletes; superoxide dismutase; supplementation; zonulin; SUPEROXIDE-DISMUTASE; ANTIOXIDANT CAPACITY; REDOX PARAMETERS; PERFORMANCE; GENERATION; PRODUCTS; OXIDANT;
D O I
10.3390/metabo13121200
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A randomized, double-blind, placebo-controlled study was conducted to investigate the influence of supplementation with a superoxide dismutase (SOD)-rich plant extract on markers of oxidative stress, zonulin levels and the performance of elite athletes. Participants were 30 international-level rowers, divided into an experimental group (n = 15) and a control group (n = 15). The rowers performed a maximal effort incremental test on a rowing ergometer at the beginning and at the end of the study. Markers of oxidative stress (total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), superoxide dismutase (SOD), glutathione peroxidase (GPx), advanced oxidation protein products (AOPPs), malondialdehyde (MDA), sulfhydryl (SH) groups, bilirubin, uric acid, albumin and zonulin) were determined in serum. A lower TOS (p = 0.010) and OSI (p = 0.004), a lower MDA (p = 0.001) and a higher level of SH groups (p = 0.031) were observed in the experimental group after supplementation. Physical performance was evaluated through metabolic efficiency, taking lactate levels and power output on the ergometer into account. After 6 weeks of supplementation, the relative increase in metabolic efficiency at a 4 mmol/L lactate concentration and maximal effort was significantly higher in the experimental group (p = 0.004 and p = 0.015, respectively). These results suggest that supplementation with a SOD-rich extract promotes lower oxidative stress, better antioxidant protection and, consequently, the better work performance of athletes.
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页数:17
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