How Supplementation with SOD-Rich Plant Extract, Combined with Gliadin, Can Affect Oxidative Stress Markers and Zonulin Levels in Exercise-Induced Oxidative Stress

被引:1
|
作者
Dudasova Petrovicova, Olina [1 ]
Stankovic, Ivan [1 ]
Dordevic, Brizita [1 ]
Dopsaj, Violeta [1 ]
Milinkovic, Neda [1 ]
Dopsaj, Milivoj [2 ]
机构
[1] Univ Belgrade, Fac Pharm, Vojvode Stepe 450, Belgrade 11221, Serbia
[2] Univ Belgrade, Fac Sport & Phys Educ, Blagoja Parovica 156, Belgrade 11000, Serbia
关键词
oxidative stress; athletes; superoxide dismutase; supplementation; zonulin; SUPEROXIDE-DISMUTASE; ANTIOXIDANT CAPACITY; REDOX PARAMETERS; PERFORMANCE; GENERATION; PRODUCTS; OXIDANT;
D O I
10.3390/metabo13121200
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A randomized, double-blind, placebo-controlled study was conducted to investigate the influence of supplementation with a superoxide dismutase (SOD)-rich plant extract on markers of oxidative stress, zonulin levels and the performance of elite athletes. Participants were 30 international-level rowers, divided into an experimental group (n = 15) and a control group (n = 15). The rowers performed a maximal effort incremental test on a rowing ergometer at the beginning and at the end of the study. Markers of oxidative stress (total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), superoxide dismutase (SOD), glutathione peroxidase (GPx), advanced oxidation protein products (AOPPs), malondialdehyde (MDA), sulfhydryl (SH) groups, bilirubin, uric acid, albumin and zonulin) were determined in serum. A lower TOS (p = 0.010) and OSI (p = 0.004), a lower MDA (p = 0.001) and a higher level of SH groups (p = 0.031) were observed in the experimental group after supplementation. Physical performance was evaluated through metabolic efficiency, taking lactate levels and power output on the ergometer into account. After 6 weeks of supplementation, the relative increase in metabolic efficiency at a 4 mmol/L lactate concentration and maximal effort was significantly higher in the experimental group (p = 0.004 and p = 0.015, respectively). These results suggest that supplementation with a SOD-rich extract promotes lower oxidative stress, better antioxidant protection and, consequently, the better work performance of athletes.
引用
收藏
页数:17
相关论文
共 50 条
  • [1] The influence of β-alanine supplementation on markers of exercise-induced oxidative stress
    Smith-Ryan, Abbie E.
    Fukuda, David H.
    Stout, Jeffrey R.
    Kendall, Kristina L.
    APPLIED PHYSIOLOGY NUTRITION AND METABOLISM, 2014, 39 (01) : 38 - 104
  • [2] Effects of grape seed extract supplementation on exercise-induced oxidative stress in rats
    Belviranli, Muaz
    Gokbel, Hakki
    Okudan, Nilsel
    Basarali, Kemal
    BRITISH JOURNAL OF NUTRITION, 2012, 108 (02) : 249 - 256
  • [3] The effect of spinach supplementation on exercise-induced oxidative stress
    Bohlooli, S.
    Barmaki, S.
    Khoshkhahesh, F.
    Nakhostin-Roohi, B.
    JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS, 2015, 55 (06): : 609 - 614
  • [4] EXERCISE-INDUCED OXIDATIVE STRESS - GLUTATHIONE SUPPLEMENTATION AND DEFICIENCY
    SEN, CK
    ATALAY, M
    HANNINEN, O
    JOURNAL OF APPLIED PHYSIOLOGY, 1994, 77 (05) : 2177 - 2187
  • [5] Grape polyphenols supplementation for exercise-induced oxidative stress
    Elejalde, Edurne
    Carmen Villaran, Mari
    Maria Alonso, Rosa
    JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION, 2021, 18 (01)
  • [6] ANTIOXIDANTS - ROLE OF SUPPLEMENTATION TO PREVENT EXERCISE-INDUCED OXIDATIVE STRESS
    GOLDFARB, AH
    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 1993, 25 (02): : 232 - 236
  • [7] Exercise-induced oxidative stress and melatonin supplementation: current evidence
    Kruk, Joanna
    Aboul-Enein, Basil Hassan
    Duchnik, Ewa
    JOURNAL OF PHYSIOLOGICAL SCIENCES, 2021, 71 (01):
  • [8] Effects of Curcumin Supplementation on Exercise-Induced Oxidative Stress in Humans
    Takahashi, M.
    Suzuki, K.
    Kim, H. K.
    Otsuka, Y.
    Imaizumi, A.
    Miyashita, M.
    Sakamoto, S.
    INTERNATIONAL JOURNAL OF SPORTS MEDICINE, 2014, 35 (06) : 469 - 475
  • [9] Effects of the antioxidant supplementation in athletes on the exercise-induced oxidative stress
    Faff, J
    BIOLOGY OF SPORT, 2001, 18 (01) : 3 - 20
  • [10] Exercise-induced oxidative stress: the effects of β-alanine supplementation in women
    A. E. Smith
    J. R. Stout
    K. L. Kendall
    D. H. Fukuda
    J. T. Cramer
    Amino Acids, 2012, 43 : 77 - 90